结直肠癌中抑癌基因ING1的表达及其意义  

Expression and Its Significance of ING1 Gene in Colorectal Carcinoma

作　　者：梁君林[1] 周永淳[1] 陈利生[1] 

机构地区：[1]广西医科大学第一附属医院结直肠肛门外科,南宁530021

出　　处：《结直肠肛门外科》2006年第5期270-272,共3页Journal of Colorectal & Anal Surgery

基　　金：广西科学基金项目(桂科回0342018);教育部留学回国启动基金项目(No:教外司留2004-176)

摘　　要：目的:探讨p33ING1在结直肠癌中的表达及意义。方法:应用免疫组化S-P法检测60例结直肠癌组织及相应正常黏膜组织中p33ING1的表达。结果:结直肠癌组织、相应正常黏膜组织中p33ING1蛋白的阳性表达率分别为43·3%(26/60)、100%(60/60)。p33ING1在无淋巴结转移组及淋巴结转移组癌组织中的阳性表达率分别为57·6%(19/33)、25·9%(7/27)(P<0·05);在Dukes A、B期、Dukes C、D期病例中分别为56·7%(17/30)、30·0%(9/30)(P<0·05)。结论:p33ING1在结直肠癌组织中低表达,在结直肠癌的发生、发展中可能起重要作用。Objective：To explore the expression of p33ING1 in colorectal carcinoma （CRC）. Methods：The expression of p33ING1 was examined immunohistochemically in 60 cases of colorectal cancerous tissues and their corresponding normal mucous tissues. Results：The positive expression rates of p33ING1 in CRC and normal mucous tissues were 43.3%（26/60） and 100%（60/60）, respectively. The positive rate of p33ING1 expression in cancerous tissues of node-negative group or Dukes A and B stages was significantly higher than that of node-positive group or Dukes C and D（57.6% VS 25.9%, 56.7% VS 30.0%）. Conclusion： Expression of p33ING1 decrease in CRC and p33ING1 may play an important role in the carcinogenesis and development of CRC.

关 键 词：结直肠肿瘤 ING1基因 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]