汉防己甲素抗钙作用对实验性大鼠脑梗塞的影响  

Experimental study on reduced cerebral Infarction sixe and menchanism of terandrine On cerebral infarction in rats

作　　者：张惠光[1] 乔香兰[1] 王明礼[1] 马青[2] 于翔辉[2] 

机构地区：[1]佳木斯医学院第一附属医院神经内科 [2]佳木斯医学院生理教研室

出　　处：《佳木斯医学院学报》1996年第5期12-14,共3页

摘　　要：本实验选用热凝造成大脑中动脑阻断(MCAO)而致实验性大鼠脑局灶性缺血型,观察了汉防己甲素(Tetrandrine TET)抗钙作用对实验性大鼠脑局灶性缺血的保护及治疗作用,并对其作用机制进行了探讨。实验结果表明;小分别(P<0.01)及(P<0.05),缺血区脑组织 Ca^(++)、Na^+、含量有关。Using thermocautery which could occlud the middle cerebal artery(MCAO)in rats to pro- duce an experimental cerebral infarction model,we studied the protective and therapeutic effects of tetrandrine on cerebral infarction in rats,then discused the mechanism of its.The results were as follows:At 7days after TET injection,the cerebral infarction size in rats with TET protected- group and TET treated-gruop was reduced compare with ischemic control-group ones(P<0. 01)and(P<0.05),cerebral Ca~、Na^(++),lever were lower evidently.The above results suggust that TET could protect and treat MCAO regional cerebral infarction,the mechanism might be that TET could reduce cerebral Ca^(++),Na^+contents.

关 键 词：汉己甲素 钙 大鼠 脑梗塞 防治 

分 类 号：R743.33[医药卫生—神经病学与精神病学]