海南黎族缺血性脑卒中患者ACE-1基因多态性研究  

Study on the ACE-1 gene polymorphism in ischemic cerebral stroke patients of LI Nationality in Hainan Province

作　　者：莫照龙[1] 卢锡林[2] 陈飞 周世锋[4] 周少珑 姚晓黎[2] 李才明[6] 

机构地区：[1]海南省农垦总局医院,海南海口570311 [2]中山大学附属第一医院神经科,广东广州510080 [3]五指山市疾病预防控制中心,海南五指山572200 [4]保亭县人民医院,海南保亭572300 [5]三亚市人民医院,海南三亚572000 [6]惠州市中心人民医院,广东惠州516001

出　　处：《中国热带医学》2006年第11期1947-1948,共2页China Tropical Medicine

基　　金：海南省自然科学基金资助项目(编号:30325);广东省博士启动基金资助项目(编号:5300783);广东省科技计划项目(编号:2006B36003003)

摘　　要：目的研究海南黎族缺血性脑卒中(IS)血管紧张素-1转换酶(ACE-1)基因多态性,旨在探讨其与IS发病易感性之间的关系。方法采用病例对照研究方法及聚合酶链反应(PCR)技术对87例海南黎族IS组及83例对照组的ACE-1基因多态性进行基因分型并计算其优势等位基因频率。结果IS患者ACE-1基因DD、ID、II基因型频率分别为6·9%、57·5%、35·6%,D等位基因频率为35·6%,I等位基因频率为64·4%;对照组的DD、ID、II基因型频率分别为4·8%、49·4%、45·8%,D等位基因频率为29·5%,I等位基因频率为70·5%;经卡方检验,两组的DD基因型及D等位基因频率比较差异无显著性意义(P>0·05)。结论研究结果未发现ACE-1基因与海南黎族缺血性脑卒中发病相关,提示ACE-1基因可能并非海南黎族人群中缺血性脑卒中相关发病基因。Objective To determine the angiotensin- 1 converting enzyme （ACE- 1） gene polymorphisms in patients with ischemic stroke in Hainan Li ethnic population and explore their association with ischemic stroke. Methods Case - control study and polymerase chain reaction method were used to test the polymorphisms of ACE - 1 in 170 subjects including 87 cases with ischemic stroke and 83 controls, then their genotypes and dominant alleles frequency were calculated. Results The frequencies of DD、ID and II genotypes of ACE - 1 gene were 6.9%, 57.5% , 35.6% respectively in patients with ischemic stroke, and were 4. 8%, 49.4%, 45.8.% respectively in the control group. The frequency of DD genotype was 4.8% in the control group and 6.9% in ischemic stroke group （ P 〉 0.05）. The frequency of D allele was 29.5% in the control group and 35.6% in the ischemic stroke （ P 〉0.05）. Conclusion ACE- 1 gene is not related to ischemic stroke, ACE - 1 gene might not be a relevant gene for patients with ischemic stroke in Li ethnic group in Hainan Province.

关 键 词：缺血性脑卒中 血管紧张素-1转换酶 基因多态性 

分 类 号：R541[医药卫生—心血管疾病]