改良人工唾液对鼻咽癌放疗患者唾液pH值和缓冲能力的影响  

Changes of Salivary pH Value and Buffer Capacity before and after Mouthrinse with Modified Artificial Saliva in Patients with Nasopharyngeal Carcinoma under Irradiation

作　　者：于晓霞[1] 金艳[1] 宋斌[1] 梁晨曦[1] 陈善义[2] 李先明[2] 陈伟[2] 

机构地区：[1]暨南大学第二临床医学院口腔医学中心,广东深圳518020 [2]暨南大学第二临床医学院肿瘤放射治疗科

出　　处：《口腔医学研究》2006年第5期475-477,共3页Journal of Oral Science Research

基　　金：深圳市科技局科研基金资助项目(编号:200304050)

摘　　要：目的:探讨改良人工唾液对鼻咽癌放疗患者全唾液pH值和缓冲能力的影响。方法:选择8例因鼻咽癌放疗并伴有口干症的患者为受试者,收集唾液时间为上午9点至11点。用改良人工唾液含漱1 m in,收集基线时及含漱后2分钟静止性及刺激性全唾液,对含漱前后静止性唾液的pH值和含漱前后刺激性唾液的缓冲能力进行测定。结果:经改良人工唾液含漱后,患者静止性全唾液pH值较含漱前为高,经统计学检验其差异具有显著性(P<0.05);患者刺激性全唾液缓冲能力大于含漱前,经统计学检验其差异具有高度显著性意义(P<0.01)。结论:改良人工唾液具有改善鼻咽癌放疗患者全唾液pH值和缓冲能力的作用。Objective： To study the effects of modified artificial saliva on the pH levels and buffer capacity in the patients with nasopharyngeal carcinoma under irradiation. Methods： Eight patients with nasopharyngeal carcinoma under irradiation used modified artificial saliva as a mouthrise. Saliva samples were collected before and 2 minutes after mouthrinse between 9：00am and 11：00am. Samples were analyzed for resting salivary pH level and paraffin - stimulated salivary buffer capacity. The effects on subjective oral symptoms were also recorded. Results： There had statistically significant increase in resting salivary pH level （ P 〈 0.05 ） and stimulated salivary buffer capacity （ P 〈 0.01 ）. Conclusion： The modified artificial saliva could improve the salivary pH and buffercapacity in the patients with nasopharyngeal carcinoma under radiotherapy.

关 键 词：人工唾液 PH值 缓冲能力 放疗 

分 类 号：R739.63[医药卫生—肿瘤]