正畸牙齿移动过程中iNOS的表达及意义  

Expression of iNOS during Experimental Tooth Movement

作　　者：李伟宏[1] 曹真胜[1] 林新平[1] 

机构地区：[1]温州医学院附属口腔医院正畸科,浙江温州325027

出　　处：《口腔医学研究》2006年第5期511-512,共2页Journal of Oral Science Research

摘　　要：目的:观察诱导型一氧化氮合酶(induc ib le n itric oxide synthase,iNOS)在大鼠正畸牙齿移动引发牙周组织改建过程中的表达,探讨NO/iNOS在正畸牙齿移动中的作用机制。方法:56只雄性SD大鼠随机分为8组。分别在正畸加力1,3,5,7,14,21,28 d后进行免疫组化染色和图像分析。结果:正畸加力3 d后,牙周组织细胞iNOS表达增强,7 d iNOS表达达到高峰(P<0.01),以后iNOS表达下降。结论:NO/iNOS参与了正畸牙周组织改建过程。Objective： To observe the expression change of inducible nitric oxide synthase （iNOS） in orthodontic periodontal tissue remodeling, learn the role of NO/iNOS during experimental tooth movement in rats. Methods： 56 male SD rats were randomly divided into 8 groups. Orthodontic appliance was placed between the maxillary right first molar and maxillary central incisors of rat. Immunohistochemistry and image analyses were performed at 0,1,3,5,7,14,21,28 days after orthodontic force application. Results： The expression of iNOS was weak immunoreactivities in normal periodotium. 3 days after tooth movement, the immunoreactivities of iNOS were increased, and reached the maximum after 7days. Conclusion： NO/iNOS participate in orthodontic periodontal tissue remodeling during tooth movement.

关 键 词：诱导型一氧化氮合酶 牙移动 

分 类 号：R783.5[医药卫生—口腔医学]