吗啡增强痛觉敏感性机制的研究进展  

The development of research for the mechanisms of morphine-induced enhanced pain sensitivity

作　　者：郑跃英[1] 祝胜美[1] 

机构地区：[1]浙江大学医学院附属第一医院麻醉科,杭州市310003

出　　处：《国际麻醉学与复苏杂志》2006年第5期320-320,I0001-I0002,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：Morphine also produces unexpected,paradoxical pain in the clinical utility for the treatment of many types of pain in addition to analgesia.Long-term morphine use is associated with tolerance,which has been recognized for long time.Recently,it has become increasingly clear that morphine-induced tolerance is accompanied with enhanced pain sensitivity,and they have some same mechanisms.This article elucidates the potential mechanisms for morphine-induced hyperalgesia and allodynia,for example,excitatory opioid receptor,NMDA receptor,anti-opioid eptids,descending facilitation system,and neuroimmune system,which maybe provide some new methods in clinical utility of morphine.Morphine also produces unexpected , paradoxical pain in the clinical utility for the treatment of many types of pain in addition to analgesia. Long-term morphine use is associated with tolerance, which has been recognized for long time. Recently, it has become increasingly clear that morphine-induced tolerance is accompanied with enhanced pain sensitivity, and they have some same mechanisms. This article elucidates the potential mechanisms for morphine-induced hyperalgesia and allodynia,for example, excitatory opioid receptor, NMDA receptor, anti-opioid eptids, descending facilitation system , and neuroimmune system, which maybe provide some new methods in clinical utility of morphine.

关 键 词：痛觉敏感性 吗啡耐受 阿片类物质 医疗工作者 用药过程 镇痛作用 反复使用 痛觉过敏 

分 类 号：R96[医药卫生—药理学]