HIF_1α在胃癌组织中的表达及临床意义  

Expression of HIF_1α and its significance in gastric cancer

作　　者：程春生[1] 贺克俭[1] 吴盛州[1] 吴雪飞[1] 张岖[1] 林木贤[1] 董卫国[2] 

机构地区：[1]深圳市南山区人民医院消化内科,深圳518052 [2]武汉大学人民医院

出　　处：《胃肠病学和肝病学杂志》2006年第5期448-450,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨HIF-1α在不同分化程度的胃癌组织中表达情况及其与胃癌生物学行为的关系。方法采用免疫组织化学S-P法,检测HIF-1α在10例正常胃组织和64例胃癌原发灶中的表达情况,并采用同济千屏影像工程公司HPIAS-2000型图像分析软件进行定量分析。结果64例胃癌中HIF-1α阳性表达54例,总阳性率为84.4%。HIF-1α在正常组织中的阳性表达率为23·79%,高、中和低分化的胃癌组织中HIF-1α阳性表达率分别为62·91%、69·83%和63·26%,在不同分化程度的胃癌组织中都强表达,均和非胃癌组织有显著性差异。结论HIF-1α在胃癌组织中表达率高,与胃癌细胞的转移、浸润、生长和黏附有关,是预测胃癌转移的一个较有价值的指标。Objective To study the expression of HIF-1α and the relationship between HIF-1αexpression and biological behavior in gastric cancer. Methods Immunohistoehemistry method of S-P was used to examine HIF-1α expression in 64 primary gastric cancer tissues, and 10 normal gastric mueosa specimens as control. Expression of HIF-1α was analyzed by HPIAS-2000 Image analysis software. Results Positive HIF-1α expression was observed in 85.9 % of the gastric cancer cases. Normal epithelial cells showed little or weak nuclear immunoreaetivity. The degree of enhancement of immunoreaetivity was different corresponding to various histopathologieal subtypes in cancer tissues. Positive HIF- 1 α expression in well, moderate and poorly differentiated adenocareinoma tissues was 62.91%, 69.83 % and 63.26 %, repeetively. When HIF- 1 α expression in gastrie cancer was compared with that in normal gastric tissues, there was a significant difference. Conclusion HIF-1 α might be a useful tumor marker for gastric cancers with respect to tumor metastasis, proliferation, cancer progression, and tumor cell adhesion.

关 键 词：胃癌 HIF-1Α 

分 类 号：R735.2[医药卫生—肿瘤]