食管癌患者血清细胞间黏附分子-1表达水平的临床意义  

Clinical significance of changes in serum sICAM-1 levels in patients with esophageal carcinoma

作　　者：俞明锋[1] 程梅[1] 

机构地区：[1]江苏省肿瘤防治研究所,南京210009

出　　处：《中国肿瘤临床与康复》2006年第5期389-390,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨细胞间黏附分子-1(sICAM-1)在食管癌患者血清表达水平的临床意义。方法应用酶联免疫吸附法(ELISA)检测58例食管癌患者和30例健康献血员血清sICAM-1的水平。结果食管癌患者sICAM-1的血清表达水平明显高于正常对照组(P<0.05);食管癌患者血清sICAM-1水平与食管癌患者的年龄、性别、病理分级无相关性,与患者的病变部位、是否有淋巴结转移有一定的相关性。结论血清sICAM-1水平可能在反映食管肿瘤的发展和转移方面具有一定的临床意义。Objective To observe the changes in serum level of soluble intercellular adhesion molecules-1 （ slCAM-1 ） in patients with esophageal carcinoma and investigate their clinical significance. Method The serum level of slCAM-1 in 58 esophageal carcinoma patients and 30 healthy subjects were measured by enzyme linked immunosorbent assay （ELISA）. Results The serum level of slCAM-1 in esophageal carcinoma patients was significantly higher than that in control group. The serum level of slCAM-1 in esophageal carcinoma patients was not correlated with age, sex and histological grade, but was clearly correlated with tumor site and lymph node metastasis. Conclusion Serum level of slCAM-1 may reflect the occurrence and metastasis of esophageal carcinoma,so it may possess certain clinical significance.

关 键 词：食管肿瘤 细胞间黏附分子-1 

分 类 号：R735.1[医药卫生—肿瘤] R730.43[医药卫生—临床医学]