CT引导下吡柔比星瘤体注入治疗肝癌的临床探讨  

Study of pirarubicin(THP) in the treatment of hepatic cancer by CT-guided intervenient therapy

作　　者：赵晨星[1] 张德耕[1] 王亚东[1] 邱山河 江绍东 沈波[3] 葛政[3] 陈凌翔[3] 

机构地区：[1]江苏省泰州市人民医院,扬州大学医学院附属医院肿瘤科 [2]江苏省泰州市人民医院CT室 [3]江苏省肿瘤医院,江苏省肿瘤防治研究所

出　　处：《中国肿瘤临床与康复》2006年第5期459-460,463,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 观察CT引导下肝癌直接注入吡柔比星（THP）的临床疗效.方法 本组16例,经CT引导下肝穿刺,吡柔比星50～70 mg/m^2,生理盐水稀释至10～30 ml,瘤体内直接注入,每3周一次,3次为一疗程,共计95例次.结果 部分缓解（PR）10例,稳定（NC）2例,恶化（PD）4例,有效率（RR）为62.5%.10例肝区胀痛治疗后,6例完全消失,2例明显缓解,2例无明显变化.11例AFP阳性,恢复正常4例, 2例明显下降,5例无变化.影像学改变：瘤体缩小,密度强弱不均,瘤体中见液化区. 组织学变化：肿瘤组织液化坏死,癌细胞变性,血管闭塞,不同程度纤维组织增生.本组患者毒副反应轻,无严重不良反应.结论 CT引导下肝癌介入治疗方法简便、安全;吡柔比星治疗肝癌疗效显著,毒副作用轻.Objective To study the efficacy of THP in the treatment of hepatic cancer by CT-guided intervenient therapy. Methods Sixteen patients were treated with THP （50-70 mg/m^2, diluted to 10-30 ml with NS） by CT-guided intervenient therapy once every three weeks. Three times constituted one course of treatment. Result There were partial response （PR） in 10 patients, no change （NC）in 2 patients and progressive disease（PD） in 4 patients. Response rate was 62.5%. In 10 patients with pain in hepatic area,the pain disappeared after the treatment in 6 patients, and was alleviated in 2 patients and not changed in 2 patients. In 3 patients with cancerous fever, the fever disappeared after the treatment. In 11 patients with high level of AFP,the AFP recovered in 4 patients, lowered in 2 and not changed in 5 patients. CT showed decrease in tumor size,internal inhomogeneous density and fluid opacity areas. Pathological examination showed cancerous tissue necrosis, vascular obliteration, hyperplasia of fibrous tissue to various degrees within the tumor. Side effects and complications were not serious. Conclusions It is suggested that the treatment with THP by CT-guided intervenient therapy is rather a safe and effective palliative therapy for hepatic cancer.

关 键 词：肝肿瘤/化学疗法 吡柔比星 CT 

分 类 号：R735.7[医药卫生—肿瘤] R730.53[医药卫生—临床医学]