食管癌放疗后Cox模型多因素分析  

Cox regression analysis of factors related to prognosis of esophageal cancer after radiotherapy

作　　者：周志国[1] 高献书[2] 张萍[1] 乔学英[1] 陈坤[1] 杨香然[1] 万钧[1] 

机构地区：[1]河北医科大学第四医院放疗科,石家庄050011 [2]北京大学第一医院

出　　处：《中华放射医学与防护杂志》2006年第5期496-498,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的利用Cox模型(比例风险模型)多因素分析食管癌放射治疗后与生存和复发相关的预后因素,同时探讨CT分期临床应用的合理性。方法对有完整CT资料的70例食管癌患者进行回顾性分析,选择CT分期在内的7个可能对预后产生影响的因素进行Cox模型多因素分析。结果CT分期、病变位置、近期疗效是食管癌放疗后生存率的主要影响因素,年龄、CT分期、病变位置是食管癌放疗后复发的主要影响因素。结论CT分期在非手术食管癌的治疗中能在一定程度上代替食管癌病理分期,指导临床治疗。Objective To study the prognostic factors in patients with cancer of the esophagus after radiotherapy using Cox proportional hazard model and to evaluate the validity of CT-staging. Methods The clinical data of 70 cases of esophageal cancer treated with radiotherapy were collected, and seven factors including CT-stage were analyzed using Cox proportional hazard model. Results The major significant factors influencing survival rate after radiotherapy were CT-stage, location of tumor and short-term curative effect, The major significant factors influencing relapse after radiotherapy were CT-stage, location of tumor and age. Conclusions CT-staging can substitute for TNM staging in some ways in non-operative treatment for patients with esophageal cancer.

关 键 词：食管癌 放射治疗 COX模型 分期 

分 类 号：R735.1[医药卫生—肿瘤]