原发性肝癌患者经导管动脉化疗栓塞治疗前后血清胰岛素样生长因子-Ⅱ检测的临床意义  

Clinical Significance of Serum Insulin-like Growth Factor-Ⅱ Measurement in Patients with Primary Hepatocellular Carcinoma before and after Transcatheter Arterial Chemoembolization

作　　者：任宗海[1] 虞希祥[1] 李荣洲[1] 林讷[1] 季婷婷[1] 蔡积武[1] 

机构地区：[1]浙江省温州医学院附属第三医院消化内科,325200

出　　处：《胃肠病学》2006年第10期605-607,共3页Chinese Journal of Gastroenterology

摘　　要：背景:血清胰岛素样生长因子-Ⅱ(IGF-Ⅱ)水平与原发性肝癌的预后有关,其检测有助于肝癌治疗效果的评价。目的:探讨经导管动脉化疗栓塞(TACE)治疗对原发性肝癌患者血清IGF-Ⅱ水平的影响,以及血清IGF-Ⅱ检测的临床意义。方法:33例接受TACE治疗的原发性肝癌患者和48例正常对照者纳入研究。以放射免疫测定检测血清IGF-Ⅱ水平。结果:原发性肝癌患者TACE治疗前后的血清IGF-Ⅱ水平均显著高于正常对照组(P<0.001);经3次TACE治疗后,患者血清IGF-Ⅱ水平较治疗前显著降低(P<0.05)。TACE治疗期间存活组血清IGF-Ⅱ水平逐渐下降,而死亡组血清IGF-Ⅱ水平与治疗前相比反而有增高的趋势,但差异无统计学意义。结论:多次TACE治疗可降低原发性肝癌患者的血清IGF-Ⅱ水平,血清IGF-Ⅱ水平可作为评价原发性肝癌TACE疗效和患者预后的指标。Background： Serum level of insulin-like growth factor- Ⅱ （IGF -Ⅱ ） is associated with the prognosis of primary hepatocellular carcinoma. Thus, serum IGF- Ⅱ measurement is helpful for the evaluation of therapeutic efficacy in primary hepatocellular carcinoma. Aims： To investigate the effect of transcatheter arterial chemoembolization （TACE） on serum IGF- Ⅱ level in patients with primary hepatocellular carcinoma, and the clinical significance of serum IGF- Ⅱ measurement. Methods： 33 patients with primary hepatocellular carcinoma received TACE therapy and 48 healthy subjects served as controls in this study. The serum levels of IGF-Ⅱ were measured by radioimmunoassay in all patients and controls. Results： The serum level of IGF- Ⅱ in patients with primary hepatocellular carcinoma beiore and after TACE treatment were all significantly higher than that in normal controls （P〈0.001）. After three times TACE treatment, the serum IGF-Ⅱ level decreased markedly than that before treatment （P〈0.05）. During the treatment period, the serum IGF-Ⅱ level decreased gradually in patients who survived and increased in those who died. Conclusions： Serum level of IGF-Ⅱ that may reduce after TACE therapy in patients with primary hepatocellular carcinoma, is a marker for the prognosis and therapeutic efficacy evaluation of TACE in patients with primary hepatocellular carcinoma.

关 键 词：肝肿瘤 胰岛素样生长因子Ⅱ 化学栓塞 治疗性 

分 类 号：R735.7[医药卫生—肿瘤]