脑室内中枢神经细胞瘤的电镜观察  

The Morphological Research on Intraventricular Central Neurocytoma

作　　者：孙异临[1] 戴建平[1] 曲宝清[1] 马振宇[1] 徐冬[1] 何雁[1] 隋大力[1] 罗士琪 

机构地区：[1]北京市神经外科研究所超微形态研究室,北京神经外科研究所神经放射研究室,北京天坛医院神经外科

出　　处：《中国医学影像学杂志》1996年第4期206-208,共3页Chinese Journal of Medical Imaging

摘　　要：中枢神经细胞瘤是来源于神经元的脑肿瘤，临床较为少见，主要好发于脑室内或室管膜下区。本文介绍了８例脑室内神经细胞瘤超微形态学研究结果。ＣＴ及ＭＲＩ神经影像学检查有明确的脑室内占位，肿瘤组织光学显微镜检查酷似少突胶质细胞瘤，细胞为圆形，大小相对一致，核周有明显空晕，钙化多见。电镜下的超微结构特点主要表现为瘤细胞胞质内有丰富的多聚核糖体、平行微管、发育较好的高尔基复合体以及由丰富的细胞突起组成的神经毡样结构，特别是非典型突触的形成及突触内大量清亮的及有致密核心的神经分泌颗粒，这些结构都显示了神经细胞分化的形态特征。本文还结合文献讨论了该肿瘤的诊断及治疗。Central neurocytoma is a rare CNS tumour of neuronal origin.It is found most commonly in young adults and usually located in the region of the lateral ventricles Eight cases of intraventricular neurocytoma were presented and the ultrastructural character of central neurocytoma was reported in this paper.CT scan and MRI examination revealed large occupying mass in the lateral ventricle and partially calcified.In the past time the pathological diagnosis of the tumor occasionally could be missed because of pathologists misinterpreting them as oligodendroglioma、ependymoma at the light microscopic level.A new concept for the intraventricular neurocytoma have been recommended since the using of the electron microscopy and the immunohistochemical technique. In our cases, electron microscopic examination showed that in general.the tumor cells had round or oval nuclei and an electron-lucent cytoplasm, where polyribosomes and mitochondria were sparsely distributed.Golgi apparatus microtubules. dense-core vesicles or clear vesicles were also found.Numerous cell processes and occasional synaptic structures were seen. The ultrastructural studies have shown that the tumor is of neuronal origin. The pathological diagnosis of central neurocytoma is mainly based on electron microscopic findings which reveal morphological features characteristic of neuronal differentiation. The diagnosis and treatment of the tumor were discussed with literature review.

关 键 词：脑肿瘤 神经细胞瘤 脑室 超微结构 

分 类 号：R739.410.4[医药卫生—肿瘤]