妊娠滋养细胞肿瘤中细胞凋亡原位观察  

A SURVEY IN SITE ON APOPTOSIS IN GESTATIONAL TROPHOBLASTIC TUMOR

作　　者：胡建功[1] 宋立刚[1] 金小平[1] 申兴斌[1] 敖亚洲[1] 王宁[1] 王竹君[1] 

机构地区：[1]承德医学院附属医院病理科,河北承德067000

出　　处：《承德医学院学报》2006年第4期353-355,共3页Journal of Chengde Medical University

摘　　要：目的:探讨妊娠滋养细胞肿瘤(GTT)中的细胞凋亡情况。方法:采用核酸原位末端标记(TUNEL)法,检测10例正常早期绒毛(NP)、10例完全性葡萄胎(CM)、20例侵袭性葡萄胎(IM)、19例绒癌(CCA)中的细胞凋亡。结果:在NP、CM、IM和CCA中,细胞凋亡指数(AI)分别为1.88%、2.59%、6.45%、1.26%,各组间差异有统计学意义,(F=7.020,P=0.000)。其中,在IM与CCA之间,差异有统计学意义(P=0.009)。结论:GTT的发生是由于机体监控能力减弱或消失、增殖与凋亡调节系统失调所致。Objective：To investigate the apoptosis in gestational trophoblastic tumor （GTT）. Methods： 10 cases of normal placenta, 10 cases of complete hydatidiform mole （CM）, 20 cases of invasive hydatidiform mole （IM） and 19 cases of choriocarcinoma（CCA） paraffin-embedded tissues were measured by terminal deoxy-nucleotidyl transferase-mediated dUTP-biotin nick end labeling （TUNEL）. Results：In NP, CM, IM and CCA, the apoptosis index （AI） was 1.88%, 2. 59%, 6.45% and 1.26% respectively with significant difference among them （F= 7. 020, P= 0.000）. There were significant difference between IM and CCA （P=0. 009）. Conclusion：The process of GTT is associated with trophoblastic cell overproliferation because the proliferation and apoptosis are out of control.

关 键 词：妊娠滋养细胞肿瘤 细胞凋亡 TUNEL 

分 类 号：R737.33[医药卫生—肿瘤]