纳米载银无机抗菌剂对义齿基托树脂细胞毒性的影响  

Influence of Nano-Silver Base Inorganic Antimicrobial on Cytotoxicity of Denture Base Resin

作　　者：佘文珺[1] 傅远飞[1] 张富强[1] 

机构地区：[1]上海交通大学医学院第九人民医院口腔修复科上海市口腔医学研究所,上海200011

出　　处：《上海交通大学学报（医学版）》2006年第10期1102-1104,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市重点学科建设基金(T0202);上海市教育发展基金(200201)资助项目

摘　　要：目的研究纳米载银无机抗菌剂对义齿基托树脂细胞毒性的影响。方法纳米载银无机抗菌剂FUMAT T200-4，按0％（对照组）、1％、2％、3％、4％、5％、7％、10％（V／V）比例添加在加热固化型义齿基托树脂中并分组，采用MTT法检测各组基托树脂对传代培养的小鼠成纤维细胞L-929的细胞毒性，比较抗菌剂添加比例对基托树脂细胞毒性的影响。结果作用于小鼠成纤维细胞后2、4、7d，各抗菌剂添加比例组基托树脂毒性反应为0级或1级，小鼠成纤维细胞相对增殖率分别为93．4％～105．9％、114．2％～147．1％和131．8％～148．8％。结论添加低浓度纳米载银无机抗菌剂FUMAT T200-4（添加比例≤10％）的基托树脂，无明显细胞毒性，具有较好的生物安全性。Objective To explore the influence of nano-silver base inorganic antimicrobial on cytotoxicity of nano-antimicrobial denture base resin. Methods The experimental groups of denture base resin were mixed with the nano-silver base inorganic antimicrobial FUMAT T2004, whose incorporating doses were 0% （control） , 1% ,2% , 3% ,4% ,5% ,7% and 10% （V/V）. Cytotoxicity in vitro on rat＇ s fibroblast was assayed with MTT method, and the grades were compared. Results After 2, 4 and 7days, the grades of cytotoxicity were 0 or 1, and the cell relative growth rates of experimental groups were 93.4%- 105. 9% , 114. 2%- 147. 1% and 131.8%- 148. 8%. Conclusion When the incorporation ratios of the nano-silver base inorganic antimicrobial FUMAT T2004 were 10% or fewer,the nano-antimicrobial denture base resin does not have cytotoxicity on small rat＇ s fibroblast and shows good biocompatibility.

关 键 词：纳米载银无机抗菌剂 基托树脂 细胞毒性 

分 类 号：R783.1[医药卫生—口腔医学]