血管紧张素原基因M235T多态性与冠状动脉病变的关系  

The Relationship Between the Angiotensiongen Gene M235T Polymorphism and Coronary Vessel Disease

作　　者：贾永平[1] 任洁[2] 吕吉元[1] 

机构地区：[1]山西医科大学第一医院心内科,山西省太原市030001 [2]太原市中心医院冠心病监护病房,山西省太原市030009

出　　处：《中国动脉硬化杂志》2006年第8期677-680,共4页Chinese Journal of Arteriosclerosis

基　　金：山西省自然科学基金项目资助(20021111)

摘　　要：目的研究我国山西及周边地区人群血管紧张素原基因M235T多态性与冠状动脉病变的关系。方法选择152名行冠状动脉造影的住院患者为研究对象,根据冠状动脉病变支数和积分分组,应用聚合酶链反应结合限制片长多态性对患者的基因型和等位基因进行分析并比较。结果冠状动脉病变支数和积分不同者,其TT基因型分布和T等位基因频率不同,该差异有显著性(χ2分别为29.537、28.560、31.970和31.771,均P<0.01)。病变支数和积分与T等位基因频率均呈正相关关系(r分别为0.396和0.395,均P<0.01)。结论血管紧张素原基因变异与冠状动脉病变支数和冠状动脉积分均具有相关性。T等位基因频率越高,冠状动脉病变支数越多,冠状动脉积分越高。Aim To study the relationship between the angiotensiongen gene M235T polymorphism and coronary vessel disease in Chinese people from Shanxi and its vicinity. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to study 152 patients who were accepted coronary angiography. Genetype and allele frequency of the patients was compared according to the number of coronary vessel disease and mean coronary heart disease （CHD） scores. Results The TT genetype and T allele frequency are different in the patients for the viration of the number of coronary vessel disease and mean CHD scores（X^2 = 29.537, 28.560, 31.970, 31.771 respectively, P〈0.01）. Positive correlation is existed in T allele frequency and the number of disease or scores（ r = 0. 396, 0. 355 respectively, P 〈 0.01 ）. Conclusions There is an association between gene variants of the angiotensinngen and the number of coronary vessel disease and mean CHD scores. The number of coronary vessel disease and mean CHD scores will be higher gradually with the increase of T allele frequency.

关 键 词：内科学 血管肾张素原 限制片长多态性 基因多态性 冠状动脉病变 基因型 等位基因频率 

分 类 号：R5[医药卫生—内科学]