VEGF家族及其受体与视网膜新生血管形成  

Vascular endothelial growth factor family & receptors and retinal neovascularization

作　　者：蒋瑶祁[1] 彭辉灿[1] 

机构地区：[1]南华大学附属第二医院眼科中心,中国湖南省衡阳市421001

出　　处：《国际眼科杂志》2006年第5期1113-1116,共4页International Eye Science

基　　金：中国湖南省教育厅资助课题(No.05C407)~~

摘　　要：视网膜新生血管形成是眼部多种疾病共有的病理改变,其造成的眼部广泛损害已成为致盲的重要原因。VEGF家族(包括VEGF-A,VEGF-B,VEGF-C,VEGF-D,VEGF-E和胎盘生长因子)作为新生血管生成中必不可少的关键因子,通过刺激血管内皮细胞的有丝分裂、迁徙、增加血管的通透性、诱导毛细血管腔的形成。本文对VEGF家族理化特性及受体、在视网膜新生血管形成中的作用和针对其作用机制采取相应防治措施进行综述。Retinal neovascularization （RNV） is the common pathological change of many ophthalmology diseases, and it is the main cause of blindness. Vascular endothelial growth factor family （include： VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and PLGF）is the key factor of RNV. Members of this family can selectively promote mitosis and metabasis of vascular endothelial cells. They also enhance the permeability of microvessel, and help to induce capillary lumen. This article mainly reviews the structure, functional characteristic, the effect of VEGF and its receptor in RNV and the measure of inhibiting neovascularization is summarized based on the action mechanism of VEGF and its receptor.

关 键 词：VEGF 受体 视网膜新生血管 

分 类 号：R774.1[医药卫生—眼科]