介入化疗对消化道肿瘤患者血清sICAM和bFGF的影响及临床意义  

Clinical significance and effects of intra-arterial chemotherapy on serum sICAM-1 and bFGF of patients with digestive system cancers

作　　者：刘登洋[1] 周宏平[2] 张艳琳[1] 狄长华[2] 

机构地区：[1]无锡市第四人民医院消化科,江苏无锡214062 [2]徐州医学院第二附属医院肿瘤科,江苏徐州221006

出　　处：《南京医科大学学报（自然科学版）》2006年第11期1077-1079,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:探讨消化道肿瘤患者介入治疗前后血清可溶性细胞间黏附分子(sICAM-1)及碱性成纤维细胞生长因子(bFGF)的变化和临床意义。方法:采用双抗体夹心法(ELISA)测定35例中晚期消化道肿瘤患者介入化疗前后血清sICAM-1和bFGF的改变,并与30例健康对照组比较分析。结果:介入化疗组治疗前sICAM-1和bFGF均明显增高,与健康对照组比较差异显著(P<0.01),伴有转移者显著高于不伴转移者(P<0.05);化疗后介入化疗组sICAM-1和bFGF显著降低,治疗前后差异显著(P<0.01)。其中介入化疗前sICAM-1和bFGF高表达者,半年后全部出现新的转移灶、病情恶化。结论:介入化疗能显著降低肿瘤患者血清sICAM-1和bFGF的水平,联合检测sICAM和bFGF有助于判断肿瘤患者的预后。Objective： To evaluate the clinical significance of serum sICAM-1 and bFGF change in digestive system cancers before and after intra-arterial chemotherapy. Methods：The levels of sICAM-1and bFGF of 35 patients with digestive system cancers before and after intra-arterial chemotherapy were measured by enzyme linked immunosorbent assay （ELISA） and compared with those of healthy controls. Results ：The levels of sICAM-1 and bFGF of patients with digestive system cancers before intra-arterial chemotherapy were higher than those of healthy controls（P 〈 0.01 ）, and were correlated to metastasis significantly（P 〈 0.05）. After intra-arterial chemotherapy, the levels of sICAM-1 and bFGF were decreased（P 〈 0.01 ）. All of the patients with high level of serum sICAM-1 and bFGF before intra-arterial chemotherapy had presented with new metastasis six months later. Conclusion：Intra-arterial chemotherapy can reduce the levels of sICAM-1 and bFGF in patients with digestive system cancers. Codetermination of sICAM-1 and bFGF may be helpful to judge prognosis.

关 键 词：消化道肿瘤 介入化疗 可溶性细胞间黏附分子-1 碱性成纤维细胞生长因子 

分 类 号：R735[医药卫生—肿瘤]