人MIF基因启动子多态性与结核病易感性的关系  

Polymorphism of Human MIF Gene Promoter and Susceptibility to Tuberculosis

作　　者：蹇锐[1] 程小星[1] 钟敏[2] 王易伟[2] 

机构地区：[1]第三军医大学微生物学教研室,重庆400038 [2]重庆市肺科医院重庆市结核基因诊断中心实验室,重庆430020

出　　处：《微生物学杂志》2006年第5期1-3,共3页Journal of Microbiology

基　　金：国家自然科学基金资助项目(30470094)

摘　　要：为了研究巨噬细胞移动抑制因子(MIF)与结核病易感性的关系,分析了肺结核病人和正常人MIF基因启动子多态性。DNA测序分析的结果显示,正常人MIF基因启动子-794区CATT序列重复次数存在明显的差异,5、6和7个拷贝的几率分别是22.2%、44.4%和33.3%。7个肺结核病人中6人有6个拷贝,1人有7个拷贝,出现的频率分别为85.6%和14.3%。对比分析提示,肺结核病人MIF基因启动子区CATT低拷贝数(低于或等于6个)出现的频率明显高于正常人(85.6%比66.6%),可能同结核病的致病相关。In order to study the relationship between macrophage migration inhibitory factor （MIF） and susceptibility to tuberculosis, mif promoter polymorphism was investigated in normal people and tuberculosis patients. DNA sequencing analysis showed that the number of CATT repeat at -794 region of mif promoter was different among normal Chinese people and the appearance of 5, 6 and 7 repeat 22.2 %, 44.4 %, and 33.3 % respectively. Of 7 lung tuberculosis patients, 6 had repeat （85.6 % ） and 1 had 7 repeat （14.3 % ）. The rate of low copy number of CATT repeat （less or equal to 6） was significantly higher in lung tuberculosis patients than in normal people （85.6 % vs 66. 6 % ）, suggesting that MIF might play a reciprocity in the pathogenesis of tuberculosis.

关 键 词：基因多态性 MIF 启动子 结核 

分 类 号：R394[医药卫生—医学遗传学] R52[医药卫生—基础医学]