26例胃肠道间质瘤的病理与免疫组化分析  

An Analysis of Pathological and Immunohistochemical Characteristics of 26 Cases of Gastriointestinal Stromal Tumor

作　　者：杨继华[1] 景丽[1] 郭凤英[1] 秦璟[2] 

机构地区：[1]宁夏医学院基础学院病理学教研室,银川750004 [2]宁夏医学院附属医院病理科,银川750004

出　　处：《宁夏医学院学报》2006年第5期381-382,385,F0003,共4页Journal of Ningxia Medical College

摘　　要：目的探讨胃肠道间质瘤(GIST)的病理形态学和免疫组织化学特点。方法采用免疫组织化学SP法观察CD117、CD34、desmin、S-100、vimentin等蛋白在26例GISTs中的表达。结果肿瘤细胞形态多变和排列方式多样,基本细胞类型为梭形细胞和上皮样细胞。免疫组化染色CD117和CD34多为弥漫强阳性,阳性率分别为76.9%和73.1%,两者表达呈正相关;Desmin、S-100及vimentin阳性率分别是26.9%、11.5%和69.2%。结论CD117、CD34在GIST免疫组织化学染色阳性率较高,可作为确诊的参考。Objective To investigate pathological and immunohistochemical gastrointestinal characteristics gastriointestinal stromal tumor（GIST）. Methods Immunohistochemisty method（SP） was applied to observe the protein expression of CD117,CD34,desmin,S-100,vimentin from 26 cases of GIST. Results Microscopically, the tumors were mainly composed of epithelioid cells, although various histological and morphological characteristics were observed. Immunohistochemically, strongly positive staining of both CD117 （76.9 % ） and CD34（73. 1% ） were detected in the tumors. Furthermore, positive correlation was found between the expression of CD117 and CD34 protein. In GIST, Desmin, S-100 and Vimentin protein with a positive rate of 26.9%, 11.5%and 69.2%, respectively. Conclusion Highly expression of CD117 and CD34 was detected in GIST, which can be considered as helpful diagnosis parameters.

关 键 词：胃肠道间质瘤 免疫组织化学 病理形态学 

分 类 号：R735[医药卫生—肿瘤]