免疫球蛋白重链和T细胞受体基因重排与急性髄细胞白血病的关系  

Immunoglobulin heavy chain and T cell receptor gene rearrangements in acute myeloid leukemia

作　　者：沈璟璟[1] 钟璐[1] 王海嵘[1] 钟济华[1] 陈芳源[1] 欧阳仁荣[1] 

机构地区：[1]上海交通大学医学院仁济医院血液科,上海200001

出　　处：《诊断学理论与实践》2006年第5期401-403,共3页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨急性髄细胞白血病(acutemyeloidleukemia,AML)患者的免疫球蛋白重链(IgH)、T细胞受体(TCR)基因重排对疾病预后的影响。方法:用聚合酶链反应(PCR)方法检测IgH、TCR基因重排。结果:38例患者中12例发生IgH基因重排(31.6%),8例TCR基因重排(21.1%)。阳性病例完全缓解率低;缓解期长的病例阳性率低;初发或复发时阳性率高。结论:IgH、TCR基因重排提示AML患者预后不良,需密切随访。Objective To investigate the clonal rearrangements of immunoglobulin heavy chain（IgH） and T cell receptor（TCR） in the patients with acute myeloid leukemia（AML） and their effect on prognosis. Methods Polymerase chain reaction（PCR） was used to study IgH and TCR gene rearrangements. Results In 38 AML patients, 12 samples（31.58%） had IgH gene rearrangements, and 8 samples（21.05%） had TCR gene rearrangements. The complete remission rate in the patients with IgH or TCR gene rearrangements was low. The rates of IgH or TCR gene rearrangements in the patients with long term remission were also low. The patients at new diagnosis or relapse had high rate of IgH or TCR gene rearrangements. Conclusions IgH and TCR gene rearrangements suggest a poor prognosis of AML.

关 键 词：急性髓细胞白血病 免疫球蛋白 重链 T细胞受体 聚合酶链反应 

分 类 号：R733.71[医药卫生—肿瘤]