心肌钾离子通道β亚单位基因KCNE1多态S38G与心房颤动的关系  

Association between human potassium channel β-subunit gene KCNE1-S38G polymorphism and atrial fibrillation

作　　者：楼盛[1] 陆林[1] 吴立群[1] 沈卫峰[1] 金奇[1] 陈秋静[1] 

机构地区：[1]上海市交通大学医学院附属瑞金医院心脏内科,上海200025

出　　处：《诊断学理论与实践》2006年第5期415-418,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨我国汉族人群心肌钾离子通道β亚单位基因KCNE1多态S38G与心房颤动(房颤)发生间的关系,并分析KCNE1-S38G在该人群中的分布特点。方法:入选房颤患者111例(病例组)及健康者101名(对照组),病例组根据基础疾病不同又分成4个亚组:孤立性房颤、高血压合并房颤、冠心病合并房颤及高血压冠心病合并房颤。采用PCR-DNA测序方法检测病例及对照组KCNE1基因编码序列,并进行统计分析。结果:病例组与对照组间,KCNE1-S38G的3种基因型频率为A/A(6.3%比11.9%)、A/G(36.9%比28.7%)、G/G(56.8%比59.4%)及A、G等位基因频率(24.8%和75.2%比26.2%和73.8%),其存在一定差异,但无显著性。各房颤亚组间比较也无显著差异。病例组各基因型间的校正QT间期(QTc)值无显著差异。结论:KCNE1-S38G在房颤患者中占一定优势,但与正常对照组相比无显著差别。KCNE1-S38G多态性位点可能存在种族、地区差异。Objective To investigate the association between atrial fibrillation （AF） and KCNE1 gene （38G or 38S） polymorphism in Chinese Han populations. Methods One hundred and eleven patients with atrial fibrillation （patients group） and 101 normal individuals （control group） were included, The patients were divided into 4 subgroups： AF alone （n=30）, hypertensive AF （n=39）, coronary heart disease （CHD） concomitant with AF （n=14）, and both hypertension and CHD concomitant with AF（n=28）. The genotype of KCNE1 was determined with polymerase chain reaction and DNA sequencing. Results No association between KCNE1-S38G and AF was found. The distributions of three genotypes （A/A, A/G, G/G） and two alleles （A and G） in the patients were not significantly different from those in the controls group. There was also no significant difference among the 4 subgroups. There was no significant difference of the corrected QT interval （QTc） among the three genotypes in the patients. Conclusions Although KCNE1-S38G allele is superior in the patients with atrial fibrillation to that in the controls, there was no significant difference between the two groups. KCNE1-S38G polymorphism may have significant ethnicity and region difference.

关 键 词：心房颤动 KCNE1-S38G 单核苷酸多态性 

分 类 号：R541.7[医药卫生—心血管疾病] R394.2[医药卫生—内科学]