NEUROG3基因突变在糖尿病人群中的筛查研究  

Mutation screening of neurogenin-3 gene in Chinese diabetic population

作　　者：郑泰山[1] 吴松华[1] 杨震[1] 陆惠娟[1] 项坤三[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病研究所,200233

出　　处：《中国糖尿病杂志》2006年第5期340-341,共2页Chinese Journal of Diabetes

基　　金：国家自然科学基金资助项目(30470813);上海市科委重点项目基金资助项目(02DJ14052-I)

摘　　要：应用直接测序方法对270名无亲缘关系的对象(其中80名为正常对照组,94例为早发性糖尿病家系先证者,96例为2型糖尿病病例)进行NEUROG3基因筛查,发现2个序列变异:在5′非翻译区的-44-45delCA及S199F变异,未发现NEUROG3基因变异与本组人群早发性糖尿病,2型糖尿病的发病相关。NEUROG3 genes were screened by direct sequencing in 270 unrelated Chinese residents, including 80 nondiabetic controls, 94 probands of early-onset diabetes pedigree and 96 type 2 diabetics. Two sequence variants were identified： -44,-45delCA and F/S199. Genetic variability in NEUROG3 gene may not be associated with early-onset diabetes, type 2 diabetes in the Chinese examined subjects.

关 键 词：早发性糖尿病 神经源素3基因 直接测序 

分 类 号：R587.1[医药卫生—内分泌]