鼻咽癌患者初诊证型的肿瘤转移相关基因活性表达特性  

An Analysis on the Differential Expressing Characters of Metastasis-Relating Genes in the Nasopharyngeal Primary Cancerous Tissues of Untreated NPC Cases with Different Patterns

作　　者：田道法[1] 刘书静[1] 曾亮[2] 何迎春[1] 刘宇勤[1] 江志超[1] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南省肿瘤医院,湖南长沙410013

出　　处：《中国中医药信息杂志》2006年第11期30-32,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30271678;30572408);国家研究生教育与学位中以基金项目([2003]46号08);国家中医药管理局中医药科研基金(02-03JP29);湖南省"十五"重点学科建设项目(2001)

摘　　要：目的探讨鼻咽癌患者初诊证型与其鼻咽病灶癌组织中肿瘤转移相关基因活性表达的相关性。方法对41例经病理确诊的初诊鼻咽癌患者进行辨证分型,同时检测其鼻咽病灶活检标本中肿瘤转移相关基因nm23-H1和VEGF165活性水平,分析nm23-H1、VEGF165基因表达活性与初诊证型的相关性。结果气阴两虚型组鼻咽原发病灶活检标本nm23-H1表达明显低于另2组,而VEGF165表达则明显高于另2组。鼻咽癌颅内侵犯型的原发灶瘤组织中肿瘤转移抑制相关基因nm23-H1呈低表达。结论气阴两虚型鼻咽癌初诊患者的鼻咽原发灶瘤组织中nm23-H1表达下调,VEGF165表达上调,与该证型增大的颅内侵犯趋势和预后不良发病机制密切相关。Objective To investigate the relationship between the differential expressing characters of metastasis-relating genes in the nasopharyngeal primary cancerous tissues of untreated nasopharyngeal cazcinoma （NPC） cases and the patterns in the terms of Traditional Chinese Medicine （TCM） manifested by these patients. Methods Forty one untreated NPC cases included were differentiated for their own patterns respectively at first and biopsys were made to take tissue samples from the nasopharyngeal mass of them for histopathological diagnosis. Furthermore, expressing level determination of metastasis-relating genes nm23-H1 and VEGF165 was carried out among these samples to analyze the correlation of expressing activity of these genes with their firstly differentiated patterns respectively. Results The expressing level of nm23-H 1 was significantly lower in the biopsied tissue samples of nasopharyngeal primary focus among the untreated NPC cases with a pattern of dual deficiency of Qi and Yin than those with the other two kinds of pattern, while the expressing level of VEGF165 was in a reverse way to that of nm23-H1 in its activity expression among these cases with the same kind of pattern （P 〈0.05）. Moreover, the expressing activity of nm23-H 1 was also significantly lower in the biopsied tissue samples of cases with the clinical type of intracranial invading than that of the other two clinical types, Conclusion The activity of nm23-H1 is expressed in a significantly down-regulated way while that of VEGF165 expressed in a significantly up-regulated way in the nasopharyngeal primary focus of NPC cases with a pattern of dual deficiency of Qi and Yin. These expressing characters of metastasis-relating genes in the nasopharyngeal primary cancerous tissues are closely related with the development of increased tendency of intracranial invading potentiality and the pathogenesis of poor clinical prognosis among this kind of cases.

关 键 词：鼻咽癌 颅内侵犯 初诊证型 肿瘤转移相关基因 

分 类 号：R739.63[医药卫生—肿瘤]