A Fast Assembly of （-）-Epigallocatechin-3-gallate [（-）-EGCG] via Intra- and Inter-molecular Mitsunobu Reaction  

作　　者：丁同健 王小龙 曹小平 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2006年第11期1618-1624,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20472025 and 20021001）.

摘　　要：This paper described a concise construction of （-）-EGCG （1f） （with an overall yield of 20% for seven steps based on the starting cinnamyl alcohol derivative 3）, featuring asymmetric dihydroxylation （ADH）, intra- and inter-molecular Mitsunobu reaction as key steps. Our strategy disclosed herein constitutes a new effective general synthetic approach toward the analogues of （-）-EGCG （1f）.This paper described a concise construction of （-）-EGCG （1f） （with an overall yield of 20% for seven steps based on the starting cinnamyl alcohol derivative 3）, featuring asymmetric dihydroxylation （ADH）, intra- and inter-molecular Mitsunobu reaction as key steps. Our strategy disclosed herein constitutes a new effective general synthetic approach toward the analogues of （-）-EGCG （1f）.

关 键 词：ADH intra- and inter-molecular Mitsunobu reaction （-）-EGCG 

分 类 号：R914.4[医药卫生—药物化学]