Biocatalytic Synthesis of Highly Enantiopure 1,4-Benzodioxane-2-carboxylic Acid and Amide  

作　　者：刘军 王德先 郑企雨 王梅祥 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China

出　　处：《Chinese Journal of Chemistry》2006年第11期1665-1668,共4页中国化学（英文版）

基　　金：Project supported by the Major State Basic Research Development Program （No. 2003CB716005）, the Ministry of Science and Technology, the National Science Foundation of China, and the Chinese Academy of Sciences.

摘　　要：Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole-cell catalyst, at 10 ℃ and with the use of methanol as a co-solvent, nitrile and amide biotransformations produce 2S-1,4-benzodioxane-2-carboxamide and 2R-1,4-benzodioxane-2-carboxylic acid in high yields with excellent enantioselectivity.Catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase and amidase containing microbial whole-cell catalyst, at 10 ℃ and with the use of methanol as a co-solvent, nitrile and amide biotransformations produce 2S-1,4-benzodioxane-2-carboxamide and 2R-1,4-benzodioxane-2-carboxylic acid in high yields with excellent enantioselectivity.

关 键 词：1 4-benzodioxane-2-carboxylic acid 1 4-benzodioxane-2-carboxamide biotransformation nitrile hydratase AMIDASE enantioselectivity 

分 类 号：O626.11[理学—有机化学]