术前应用平阳霉素化疗配合改良手术治疗阴茎癌疗效的初步观察  

Initial Study of Pre-operational pingyangmycin Chemotherapy plus Improved Operation in Treating Penile Cancer

作　　者：乔忠杰[1] 赵丕显[1] 陈辉[1] 崔岩[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150181

出　　处：《现代生物医学进展》2006年第10期76-76,80,共2页Progress in Modern Biomedicine

摘　　要：目的：探讨应用平阳霉素化疗配合改良手术治疗阴茎癌的治疗效果。方法：104例阴茎癌患者,平均年龄55．3岁,手术前皆进行病例组织活检证实,术前应用平阳霉素化疗7～14天,并在化疗后行阴茎部分切除术+改良方法的腹股沟淋巴结清扫术。观察术后情况,并进行艰踪随访。结果：所有患者化疗反应轻微,化疗后肿瘤明显缩小者26．9％,肿瘤脱落者6．9％。无变化者23．7％。术后皮瓣严重坏死者14．4％；轻度坏死者13．5％；无坏死者72．1％。出现下肢水肿者24．O％。随访4～10年,正常存活46．6％；出现远处转移者18．3％；死亡17．1％。结论：术前应用平阳霉素化疗可使部分阴茎癌组织明显缩小,甚至瘤体脱落,手术可最大范围地保留阴茎功能。改良腹股沟淋巴结清扫术缩小了清扫范围,减轻了下肢及阴囊水肿,提高了患者的生活质量和生存率。Objective： To investigate the effects of Pingyangmycin chemotherapy plus improved operation in treating penile cancer. Methods： 104 cases of patients with penile cancer were studied, whose mean age was 55.3 years old. They ,were all proved squamous cell carcinoma by biopsy. After 7 - 14 days of using Pingyangmycin, the patients underwent partial penectomy and improved bilateral inguinal lymphadenectomy. The clinical changes of the patients were observed after operation, and they were followed up after leaving hospital. Results： All the patients were suffered from slight chemotherapy reaction; after chemotierapy, the patients with tumors obviously reduced were 26.9%, fell off, 6.9%, no changes, 23.7%. Gross skin valve necrosis were 14.4%, slight necrosis, 13.5%; no necrosis, 72.1%, lower limbs edema, 24.0%. After followed up for4-10 years, the patients normally survived were 46.6%, distant metastasis, 18.3% ; and the dead were 17.1%. Conclusion： Pre - operatively using Pingyangmycin chemotherapy can greatly reduce the size of cancer tissues of penis, even making them fall off, which could retain the function of penis to the full extent. The improved bilateral inguinal lymphadenectomy may reduce the resection scale and lighten the edema of lower limbs, which increases the life quality and survival rate of the patients.

关 键 词：平阳霉素 术前化疗 阴茎癌 疗效 

分 类 号：R737.27[医药卫生—肿瘤]