Phylogenetic Analysis of RhoGAP Domain-Containing Proteins  

作　　者：Marcelo M. Brando Karina L. Silva-Brando Fernando F. Costa Sara T.O. Saad 

机构地区：[1]Hematology and Hemotherapy Center, State University of Campinas, 13083-970 Campinas, SP, Brazil [2]Department of Zoology, Institute of Biology, State University of Campinas, 13083-970 Campinas, SP, Brazil.

出　　处：《Genomics, Proteomics & Bioinformatics》2006年第3期182-188,共7页基因组蛋白质组与生物信息学报（英文版）

摘　　要：Proteins containing an Rho GTPase-activating protein （RhoGAP） domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes comes from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing proteins. The sequences were aligned by their RhoGAP domains and the phylogenetic hypotheses were generated using Maximum Parsimony and Bayesian analyses. The character tracing of two traits, GTPase activity and presence of other domains, indicated a significant phylogenetic signal for both of them.Proteins containing an Rho GTPase-activating protein （RhoGAP） domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes comes from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their intrinsic GTPase activity. Here, a phylogenetic approach was applied to study the evolutionary relationship among 59 RhoGAP domain-containing proteins. The sequences were aligned by their RhoGAP domains and the phylogenetic hypotheses were generated using Maximum Parsimony and Bayesian analyses. The character tracing of two traits, GTPase activity and presence of other domains, indicated a significant phylogenetic signal for both of them.

关 键 词：Bayesian analysis character tracing PARSIMONY PHYLOGENOMICS protein domain RhoGAP 

分 类 号：Q51[生物学—生物化学]