生长因子缓释制剂在神经系统退变性疾病中的应用  

Application of control-release preparations of growth factor in treating neurodegeneration diseases

作　　者：谷海刚[1] 宋存先[2] 

机构地区：[1]中国医学科学院中国协和医科大学生物医学工程所,天津300192 [2]天津市生物医学材料重点实验室

出　　处：《国际生物医学工程杂志》2006年第5期292-296,共5页International Journal of Biomedical Engineering

基　　金：天津市重点资助项目(043803011);国家自然科学基金资助项目(50473059);博士点基金资助项目(20030023004)

摘　　要：利用缓释系统包载生长因子,既能保护生长因子的生物活性,又可以使其缓慢释放。从载体材料与生长因子的简单混合到生长因子缓释微球系统,生长因子缓释技术不断更新并得到广泛应用。就生物可降解生长因子缓释制剂在神经系统退变性疾病中的应用做一综述。Incorporation of growth factors in polymeric drug delivery systems serves to maintain its bioactivity and long-term sustained release. With the development of controlled release techniques from simple mixing growth factors with carrier materials to controlled release microspheres, this kind of delivery formulations gain their extensive application. The present review focused on the application of biodegradable delivery systems of growth factors in treating neurodegeneration diseases.

关 键 词：生物可降解制剂 生长因子 神经系统退变性疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]