201例盘状红斑狼疮的临床、病理与免疫金银染色检测分析  

Analysis of the clinic with pathology and detection using IGSS of 201 cases of discoid Lupus Erythematosus

作　　者：张水龙[1] 周曾同[1] 曹宏康[1] 许国祺[1] 

机构地区：[1]上海第二医科大学口腔医学院口腔内科教研室

出　　处：《上海口腔医学》1996年第3期132-134,共3页Shanghai Journal of Stomatology

摘　　要：作者对２０１例盘状红斑狼疮的临床、病理与免疫金银染色检测作了分析。结果显示：损害好发于下唇（６０％）。在系统因素中，患消化系统疾病为２５％，占首位。全部病例均经病理证实，其中８例伴有轻度上皮异常增生，３例发生癌变，１例盘状红斑狼疮和扁平苔藓共存。免疫金银染色检测显示：在组织切片的基底膜区除了有Ｆｇ的沉积之外，尚有多类免疫球蛋白或多类免疫球蛋白伴补体Ｃ３的共同沉积。说明盘状红斑狼疮是一种由多种因素引起的自身免疫性疾病，具有癌变可能，盘状红斑狼疮与扁平苔藓共存现象可能提示是一种疾病的不同发病阶段，其机理有待于作更深入的研究。Clinic pathology and detection using IGSS of 201 cases of discoid lupus erythematosus(DLE) were studied in this paper.The results showed : 1. DLE usually occuredon the low lip(60%); 2. Suffering from gastrointestinal disease were the first symptom(25%); 3. 201 DLE cases was confirmed by mild dysplasia, 3 caese of carcinoma, 1 case Combined of DLE and lichen planus(LP);4. Immunogold-silver Staining(IGSS) was applied to detect immune complex. The result indicated that Fg, immunoglobins and complement C3 deposited at basal membrane zone of DLE. It is illustrated that DLE is an autoimmune disease which is caused by many kinds of factors and may be cancerous. Coexistence of DLE and LP suggested that they may be at different stages of the same disease. Its mechanism will be further studied.

关 键 词：盘状红斑狼疮 病理学 免疫金银染色 

分 类 号：R781.5[医药卫生—口腔医学]