临床试验中多维生存时间资料的分析  

Analysis of multivariate of time-to-even in clinical trial

作　　者：苏霞[1] 钱国华[1] 荀鹏程[1] 于浩[1] 郎素平[1] 陈峰[1] 

机构地区：[1]南京医科大学公共卫生学院

出　　处：《中国临床药理学与治疗学》2006年第9期1073-1077,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：本文介绍了PWP模型的原理及其在处理多元生存实际资料方面的应用技巧。通过实例分析显示该方法在实际应用中可以很好地处理多个终点事件的资料,并通过限制模型中参数的取值,得到分析协变量对不同终点事件的影响是否相同。表明PWP模型是一种有效地处理多维生存时间资料的分析方法。This paper discussed the analysis of multivariate of time to even （rITE） or survival-time data. It introduces the principle of PWP model and the applied technique of PWP model in dealing with the actual multivariate survival-time data. The results show that this method is good at dealing with multivariate outcome event, and it can obtain the effect of concomitant variable to the different outcome events to limit the parametric value of the model. PWP model is an efficient analytical method for dealing with multivariate survival-time data.

关 键 词：多维生存时间资料 PWP模型 多元比例 风险模型 

分 类 号：R311[医药卫生—基础医学]