丽珠胃三联根除慢性胃炎和消化性溃疡幽门螺杆菌感染的研究  

The study on eradication of Hp with livzon weisanlian in the patients suffered from Hp associated chronic gastritis and peptic ulcer

作　　者：胡友莹[1] 胡联华[2] 王克霞[1] 张荣波[1] 

机构地区：[1]安徽理工大学医学院病原微生物教研室,安徽省淮南232001 [2]安徽理工大学附属医院

出　　处：《中国基层医药》2006年第10期1601-1602,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省教育厅自然科学研究项目(2003kj111)

摘　　要：目的 了解安徽淮南地区慢性胃炎和消化性溃疡幽门螺杆菌（Hp）感染情况，探讨丽珠胃三联根除Hp的疗效。方法 在内镜下诊断为慢性胃炎和消化性溃疡的患者，于胃窦部距离幽门约3～5cm和胃体部大弯侧分别夹取2块胃黏膜组织，用于尿素酶检查、直接涂片镜检和病理组织学检查，尿素酶检查与后两项检查任一项阳性者为Hp感染。Hp阳性患者均给予丽珠胃三联（枸橼酸铋钾、替硝唑、克拉霉素）。结果慢性浅表性胃炎（CSG）Hp阳性率为81．6％，慢性萎缩性胃炎（CAG）Hp阳性率为63％，胃溃疡（GU）Hp阳性率为90．8％．十二指肠溃疡（DU）Hp阳性率为93．3％；丽珠胃三联根除慢性胃炎和消化性溃疡Hp感染有一定的疗效，根除率为86．5％。结论 该地区慢性胃炎和消化性溃疡患者Hp阳性率较高，丽珠胃三联治疗该地区Hp阳性的慢性胃炎和消化性溃疡．根除率高，适宜用丽珠胃三联根除该地区Hp感染患者。Objective To investigate the effect of livzon weisanlian（bismuth agent 0.22g,bid ＋ tinidazole, 0.5g, bid ＋ clarithromycin 0.25g, bid） for 7 days for eradication of H, pylorl and infection of patients suffering from chronic gastritis and peptic ulcer in Huannai area. Methods Four pieces of gastric mucosa were taken out by gastroscopy,two pieces of them from gastric antrum 3 ~ 5cm near pylori and the others from gastric body. All of them were detected for H. pylori and biopsy and smear. If both the former and the one of the later are all positive the patient was diagnosed with H. pylori and treated with livzon weisanlian. Results The positive of CSG is 81.6 % ,CAG is 63 % ,GU is 90.8 % and DU is 93.3 % . Conclusion The positive rate of patients suffering from chronic gastritis and peptic ulcer in Huainan area is high. The eradicative rate with livzon weisanlian is also high and it shows that livzon weisanlian is feasible to treat chronic gastritis and peptic ulcer.

关 键 词：丽珠胃三联 胃炎 消化性溃疡 螺杆菌 幽门 

分 类 号：R573[医药卫生—消化系统]