大豆胚轴中异黄酮的提取及其抗血小板聚集作用的研究  

EXTRACTION OF ISOFLAVONES FROM SOYBEAN HYPOCOTYL AND THEIR ANTI-PLATLET AGGREGATIVE EFFECT

作　　者：全吉淑[1] 尹学哲[1] 工藤重光 

机构地区：[1]延边大学医学院,吉林延吉133000 [2]日本东北食效科学研究所

出　　处：《食品研究与开发》2006年第10期57-59,共3页Food Research and Development

基　　金：国家自然科学基金资助项目(30360113)

摘　　要：从大豆胚轴提取总糖苷后,采用C18反相柱层析法分离大豆异黄酮糖苷,再将其水解制备成异黄酮苷元,并研究大豆异黄酮对人血小板聚集性的影响。结果:在体外人血小板聚集实验中,大豆异黄酮苷元均抑制ADP、胶原蛋白和肾上腺素诱导的血小板聚集。提示:大豆异黄酮可能有助于防止血栓形成。Total glycosides were extracted from soybean hypocotyl, then isoflavone glycosides were isolated with C18 reversed phase column chromatography. Finally isoflavone aglycones were prepared by hydrolysis of isoflavone glycosides and their influence on aggregation of human platelets were studied. It was resulted that isoflavone aglycones inhibited human platelet aggregation induced by ADP, collagen and epinephrine. The results suggest soybean isoflavones may be useful for the prevention of thrombus formation.

关 键 词：大豆胚轴 异黄酮 血小板聚集 

分 类 号：R151[医药卫生—营养与食品卫生学]