用L—652，731初筛抗PAF活性成分的简易方法  

Establishment of A Simple Method to Screen The Anti-paf Constituent from Medicinal Plants by Using Synthetic L-652,731 Antigonist

作　　者：邓克敏[1] 徐佩娟[1] 黄霞萍[1] 陈聪颖[1] 陈泽乃[1] 

机构地区：[1]上海第二医科大学化学教研室,上海第二医科大学附属瑞金医院出凝血实验室

出　　处：《上海第二医科大学学报》1996年第5期315-317,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：国家自然科学基金

摘　　要：血小板活化因子（ＰＡＦ）作为受体的介质而与炎症、过敏等多种生理过程有关。作者介绍一种简易的血小板聚集玻片法用以从药用植物中初筛抗ＰＡＦ活性成分，并合成了Ｌ—６５２，７３１且以其作为标准拮抗剂。In order to screening the anti-PAF constituents from medicinal plants,a simple smear method was used to observe the aggregation of blood platelets induced by PAF under microscrope. The results were divided into four grades with L-652,731 as a standard antagonist.This method was compared with Born's turbidimetric method and applied in screening different fractions isolated from Fritillaria Ussuriensis。

关 键 词：血小板活化因子 筛选法 L-652 731 拮抗剂 

分 类 号：R965.1[医药卫生—药理学]