肝硬化患者血浆儿茶酚胺、甲状旁腺素含量与肝肾综合征的关系  

SAS,PTH IN CIRRHOSIS AND HEPATORENAL SYNDROME:RELATIONSHIP WITH WATER AND SODIUM RETENTION

作　　者：张练[1] 徐葆元[1] 

机构地区：[1]重庆医科大学第二医院内科,630010

出　　处：《重庆医学》1996年第5期262-265,共4页Chongqing medicine

摘　　要：本研究探讨肝硬化腹水及肝肾综合征(HRS)的发病机理。结果表明:肝硬化腹水时有明显的水钠潴留,晚期出现肾功能异常;肝硬化时交感肾上腺系统(SAS)活动增强,尤以肝肾综合征患者为明显;甲状旁腺素(PTH)在肝硬化代偿期,失代偿期及HRS时均显著升高。The sympathetic - adrenal system (SAS) and parathyroid hormone (PTH) in relation with sodium retention were studied in 17 patients with compensated cirrhosis (CC) ,26 decom-penensaetes cirrhosis (DC),6 hepatorenal syndrome(HRS)and 20 normal controls(NC),Our results showed that there was a signiicant sodium retention in patients with CC,DC and HRS, in whomcreatinine clearence (Ccr) decreased,whereas plasma noradrenaline(PNA) ,adrenaline (PA)and PTH concentration were all significantly increased,they were higher in DC than that in CC,and highest in HRS. In addition,PNA and PTH were negatively correlated with Ccr and urinary sodium excretion in 24 hours.It suggested that the enhanced activities of SAS and PTH play an important role in sodi-um retention and development of HRS.

关 键 词：肝肾综合征 肝硬变 儿茶酚胺 甲状穿腺素 

分 类 号：R575.206[医药卫生—消化系统] R692.02[医药卫生—内科学]