肺癌患者血清细胞外基质指标变化的临床意义  

The clinical significance of detecting four indexes of serum extracellular matrix in lung cancer patients

作　　者：康卫国 刘久山[2] 朱建军[2] 蔡绍曦[2] 翁介月[2] 

机构地区：[1]148医院,山东淄博255300 [2]广州南方医科大学南方医院,广东广州510000

出　　处：《实用医药杂志》2006年第11期1317-1318,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的检测肺癌患者血清中细胞外基质(ECM)的变化情况,并探讨其临床意义。方法用放射免疫法检测39例肺癌患者的血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(CⅣ;以下简称基质四项),与对照组30例进行对比。结果肺癌患者血清基质四项比对照组显著升高(P<0．05),肺癌胸外转移患者的血清PCⅢ和CⅣ比肺癌胸内转移者显著升高(P<0．05),肺癌不同细胞类型之间的血清基质四项无显著性差异。结论肺癌患者的血清细胞外基质指标有明显异常,这对于肺癌的诊断、转移程度的观察、治疗效果的评价以及转移机理的研究都有重要价值。Objective To detect changes of four indexes of extraeellular matrix （ECM） in lung cancer patients and explore their clinical significance.Method The serum hyaluronie acid, laminin, proeollagen m and collagen Ⅳ（also celled as four-ECM-marker） were detected in lung cancer patients. The results were compared with that of normal control g,-oup.Results The serum levels of four-ECM-maker were obviously higher than control group. The serum level of procollagen Ⅲ and collagen Ⅳ was markedly higher in patients with metastasis out of thorax than in of thorax. There was no difference of the serum four-ECM-marker in various cells type of cancer.Conclusion The serum four-ECM-marker is distinctly abnormal in lung cancer.it is valuable for diagnosis of lung cancer, evaluation of treatment effective, observation of severity of metastasis and investigation of metastasis mechanism of lung cancer.

关 键 词：肺癌 细胞外基质 血清 

分 类 号：R734.2[医药卫生—肿瘤] R446.112[医药卫生—临床医学]