缺氧－复氧损伤对大鼠脊髓组织牛磺酸转运的影响  

Effects of Anoxia-reoxygenation on Taurine Transfer of Rat Spinal Cord

作　　者：叶赤[1] 常英姿[1] 苏静怡[1] 唐朝枢[1] 王吉先[1] 刘兰英[1] 

机构地区：[1]北京医科大学心血管研究所,山东铝业公司职工医院

出　　处：《基础医学与临床》1996年第5期364-366,共3页Basic and Clinical Medicine

摘　　要：本工作在大鼠离体脊髓缺氧－复氧损伤模型上，观察了脊髓组织牛磺酸转运的特征，结果发现：缺氧４５ｍｉｎ后复氧孵育１５ｍｉｎ，脊髓组织出现明显的牛磺酸转运的障碍，表现为Ｖ＿（ｍａｘ）明显降低（为正常组的７１％，Ｐ＜０．０１），Ｋｍ值无明显改变，推测缺氧。复氧可能通过影响能量代谢而导致脊髓组织牛磺酸转运的障碍。he characteristics of taurine transfer was investigated on anoxia-reoxygenation model ofisolated rat spinal cord.The results showed after 45 min anoxia and 15 min reoxygenation,taurinetransfer of spinal cord was significantly reduced,it manifested that Vmax decreased(71%of con-trol,P<0. 01),Km was not changed.It mdwy be infered that anoxia-reoxygenation decreases thetransfer of spinal cord through dysfunction of energy metabolism.

关 键 词：缺氧 复氧 脊髓损伤 

分 类 号：R744.02[医药卫生—神经病学与精神病学]