辛伐他汀抑制正畸牙齿移动后复发距离的实验研究  

An experimental study of simvastatin inhibiting the relapse distance after orthodontic tooth movement

作　　者：韩光红[1] 陈远萍[1] 侯建华[1] 孙华丽[2] 

机构地区：[1]吉林大学口腔医学院正畸科,长春130041 [2]吉林省人民医院口腔科

出　　处：《现代口腔医学杂志》2006年第6期621-623,共3页Journal of Modern Stomatology

基　　金：吉林大学创新基金项目(2004-2005)

摘　　要：目的探讨全身给予辛伐他汀对大鼠实验性牙移动后牙齿复发距离的影响。方法选用32只雄性Wistar大鼠,随机分成4组:对照组(生理盐水)、低剂量组(2.5mg/kg)、中剂量组(5.0mg/kg)、高剂量组(10.0mg/kg),牵引其上颌第一磨牙向近中移动。实验组在加力装置去除前1天开始,腹膜下注射辛伐他汀,对照组注射生理盐水,每日1次,连续4周。分别在加力装置去除时及其后1周、4周,测量上颌第一、第二磨牙间距离,测量体重。结果①各组大鼠体重无明显变化(P>0.05)。②低、中、高剂量组大鼠牙齿移动复发距离小于对照组(P<0.05)、复发百分率明显低于对照组(P<0.01),且剂量越小复发程度越小,低剂量组复发百分率最低。结论辛伐他汀能有效地抑制实验性牙移动后牙齿复发的程度,低剂量时效果最明显。Objective To investigate the effects of systematic administration of simvastatin solution on the relapse distance after the tooth movement. Methods Orthodontic tooth movement of upper first molar was performed in 32 rats with coil spring for 21 days. Thirty- two rats were randomly allocated into 4 groups： Three simvastatin groups （2.5mg/kg, 5.0mg/kg and 10.0mg/kg） and the control group. The experimental groups were administered simvastatin daily at 1 day before appliances removed. The control group received the isotonic saline instead. Four weeks later all animals were deeply anesthetized and killed. The interdental distance between the first and second maxillary molars was measured, separately when appliances were removed after 1 week, 4 weeks. At the same time, weight of rat was measured. Results ①Simvastatin had no significant influence on the body weights（ P 〉 0.05）. ②Between experimental groups and the control group,the total amount of relapse, the anteriors were lower than the latter（ P 〈0.05） ; and the percentage of relapse, the anteriors were significantly lower than the latter （ P 〈 0.01）. The lower dose, the less extent relapsed. In the low - dose group, the percentage of relapse was the lowest in experimental groups. Conclusion The study indicates that a single systemic administration of simvastatin decreases the extent of initial relapse in experimentally moved rat molars, especially low- dose simvastatin has more significantly effect.

关 键 词：辛伐他汀 牙移动 正畸 复发 

分 类 号：R783.5[医药卫生—口腔医学]