胃癌患者EB病毒感染与Cyclin D1基因表达的相关性  

Relativity between EBV infection and expression of Cyclin D1 in gastric carcinoma patients

作　　者：李淑英[1] 张科[2] 周天戟[1] 

机构地区：[1]华北煤炭医学院生物科学系微生物学科,河北唐山063000 [2]华北煤炭医学院成人教育学院函授科,河北唐山063000

出　　处：《第四军医大学学报》2006年第21期1932-1933,共2页Journal of the Fourth Military Medical University

基　　金：教育部留学回国人员科研启动基金(教外司留[2000]479)

摘　　要：目的:研究胃癌患者癌组织中EB病毒(EBV)感染与CyclinD1表达的关系.方法:原位杂交法检测胃癌患者石蜡标本中EBV编码的小RNA(EBER1);免疫组化法检测EBV阳性胃癌[EBV(+)]及EBV阴性胃癌[EBV(-)]标本细胞周期蛋白Cyclin D1的表达状况.结果:胃癌患者癌组织标本217例中23例EBER1(+);EBV(+)组Cyclin D1蛋白表达显著高于EBV(-)组(P<0.01).结论:EBV感染可能上调CyclinD1表达.AIM： To investigate the relativity between the Epstein-Barr Virus （EBV） infection and the expression of Cyelin D1 in gastric carcinoma （GC） patients. METHODS ： EBER1 in 217 cases of GC was detected with in situ hybridization. Then, EBV positive and negative GC cases were selected for analysis of the expression of Cyclin D1 by immunohistochemistry. RESULTS： In 217 GC cases there were 23 cases with EBER1 positive expression. The expression of Cyclin D1 was higher in the EBV positive GC than that in the EBV negative （ P 〈 0. 01 ）. CONCLUSION： EBV infection in GC may upregulate the expression of Cyclin D1.

关 键 词：疱疹病毒4型 人 胃肿瘤 癌基因蛋白质类 

分 类 号：R735.2[医药卫生—肿瘤]