24小时食管胃pH监测的临床应用  

Clinical application of 24-hour esophageal and intragastric pH monitering in 100subjects

作　　者：吴本俨[1] 王孟薇[1] 李园[1] 张子其[1] 

机构地区：[1]解放军总医院南楼五科

出　　处：《军医进修学院学报》1996年第4期265-269,共5页Academic Journal of Pla Postgraduate Medical School

摘　　要：测定３２例受试者２４ｈ食管ｐＨ节律变化，证实胃食管反流病患者与对照组比较，酸反流得分及其他酸反流指标均有明显不同。５例仪有食管反流症状，胃镜检查无食管炎的患者，经食管ｐＨ检测酸反流得分异常，确诊为胃食管反流病。提示食管ｐＨ监测对诊断胃食管反流病具敏感性高和特异性强的优点。不同年龄健康人胃ｐＨ测定表明，青、老年人中位ｐＨ值、基线ｐＨ值、ｐＨ＜２的百分比时间均无明显不同。老年人餐后下降期时间、进餐峰值期ｐＨ较青年人延长。十二指肠球部溃疡患者胃内ｐＨ节律变化与健康人比较有明显不同，其突出特点是中位ｐＨ值低，ｐＨ＜２的百分比时间明显增高，夜间胃内ｐＨ值明显较健康人低，提示２４ｈ胃ｐＨ测定对了解胃酸生理性分泌和胃内酸度可提供客观依据。The changes of esophageal pH rhythm in 32 subjects and intragastric pH in 68 subjccts werere-searched by using 24 hour pH monitering,Compared with healthy subjects,patients with gastroesophageal reflux disease(GERD)had signiflcant differences in total percentage time at pH<4,supine and upright frac-tion time at pH<4,number of reflux episodes and the longest reflux time at pH<4,GERD was demonstrated by using pH monitering in 5 patients with esophageal reflux symptoms but without esophagitis by endoscopy.Monitering of 24 hour intragastric pH showed that the level of median pH,baseline pH,percentage time of pH<2 were similar in healthy suUects of dlfferent age groups.But the postprandial decline phase and prandial plateau pha:ewere longer in the aged than that in the younger.The value of median pH was lower and accumulated percentage time of pH<2was longer in patients with duodenal ulcer than that in healthy subjects.It is suggested that the 24 hour pH monitering is an accurate and sensitive mehiod for reflecting of gastroesophageal reflux and intragastric hydrogen ion activity.

关 键 词：胃肠疾病 胃酸测定 氢离子浓度 临床应用 

分 类 号：R570.4[医药卫生—消化系统]