星形胶质细胞瘤MR诊断有关定量参数研究  

The Evaluation of MRI Quantitative Parameters in Diagnosing Cerebral Astrocyte Gliomas

作　　者：耿道颖[1] 沈天真[1] 陈星荣[1] 

机构地区：[1]上海医科大学华山医院放射科

出　　处：《中国医学计算机成像杂志》1996年第2期75-79,共5页Chinese Computed Medical Imaging

摘　　要：目的：建立一组ＭＲ定量诊断参数并比较其在星形胶质细胞瘤定性定级诊断中的价值。材料和方法：８０例星形胶质细胞瘤均经术前ＭＲＩ诊断，手术与病理证实，测定常规ＭＲ参数即Ｔ１Ｔ２值，Ｔ１ＷＩ、Ｔ２．ＷＩ上的相对信号强度（ＲＳＴ）。及Ｔ２ＷＩ上的相对信号不均匀性（ＲＳＨ）；增强后ＭＲ参数包括ＲＳＩＧｄ、增强百分率、和ＲＳＨＧｄ．以及磁传递成像参数即ＭＴ效应和ＭＴＲ。结果：低度恶性与高度恶性星形胶质细胞瘤的ＲＳＩ和ＲＳＨ差别具有显著性（Ｐ＜０．０５）。随着肿瘤恶性度的升高，Ｔ１、Ｔ２驰豫时间有缩短倾向，但交叉重叠较多（Ｐ＞０．０５）。增强后ＲＳＩＧｄ在低度恶性与高度恶性星形胶质细胞瘤之间差异显著（Ｐ＜０．００１）．且１．１６可作为区别低度恶性与高度恶性星形胶质细胞瘤的界值。本组符合率在８５％以上。所有肿瘤的ＭＴ效应均小于脑白质；且高度恶性星形胶质细胞瘤的ＭＴ效应和ＭＴＲ均大于低度恶性者（Ｐ＜０．００１）。结论：增强前后ＲＳＩ和ＲＳＨ对肿瘤的定性定级诊断价值很大；ＭＴＲ在区别肿瘤的良恶性方面优于常规ＭＲ参数。Constructing a category of quantitative diagnostic parameters,for comparing the reliability of quantitative parameters in conventional T1 - and T2 - weighted MR imaging for the classification of Astrocyte gliomas.Materials and Methods:80patients with astrocytic gliomas were imaged preoperatively and proved by operation and pathology.The T1、T2 value;the relative signal intensities on T1 - and T2 - weighted and Gd-enhanced T1 - weighted imagings and MT ratios were measured.Results:conventiOnal quantitative parameters;RSI= 0.66- 0.76 in gra del-2;RSIGd>1.16 in grade3-4.Post-contrast tumor hetergeneity on MRI increased proportion ally with the gradation of malignancies.MTR of gradel-2and grade3-4were 0.44-0.52,0.71-0.81 respectively(P<0.001)Conclusion:RSI and RSH were related to different grades of gliomas.MT ratios were supereior to quantitative parameter of conventional MR imging in grading gliomas.

关 键 词：星形胶质细胞瘤 定量参数 MRI 成像 诊断 

分 类 号：R730.264[医药卫生—肿瘤]