慢性萎缩性胃炎黏膜上皮中P53和C-erbB-2表达的临床意义  

Expression of P53 and C-erbB-2 and their significances in chronic atrophic gastritis

作　　者：赵松[1] 付英梅[2] 赵柏[3] 刘连新[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院普外科,黑龙江省哈尔滨市150001 [2]哈尔滨医科大学微生物教研室,黑龙江省哈尔滨市150086 [3]哈尔滨医科大学第二临床医学院泌尿外科,黑龙江省哈尔滨市150086

出　　处：《世界华人消化杂志》2006年第30期2943-2947,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨慢性萎缩性胃炎(CAG)黏膜上皮中P53及C-erbB-2的表达及意义．方法:用免疫组化技术(SP法)检测正常胃黏膜56例、慢性萎缩性胃炎429例(腺体囊性扩张61例,大肠型化生73例,轻、中、重度不典型增生各120、91和84例)和早期胃癌57例中P53和C-erbB-2的表达,分析P53和C-erbB-2表达及其与CAG胃黏膜病变类型的关系．结果:正常胃黏膜,囊性扩张腺体,轻、中度不典型增生,大肠型化生,重度不典型增生,早期胃癌P53和C-erbB-2表达的阳性率呈上升趋势．前三组间表达率差异无统计学意义(P>0．05);正常胃黏膜与中度不典型增生、大肠型化生、重度不典型增生及胃癌组P53和C-erbB-2的表达差异有统计学意义(P<0．01)．Spearman等级相关分析显示P53和C-efbB-2表达呈正相关(r=0．867,P<0．05)．年龄<40岁和≥40岁组间、性别组间P53表达阳性率差异有统计学意义(x2=12．393,P<0．01;x2=8．799, P<0．01)．C-erbB-2的表达在上述年龄组间差异有统计学意义(x2=7．706,P<0．01),而在性别组间无统计学意义(P>0．05)．结论:检测慢性萎缩性胃炎中P53和C-erbB-2的表达,有助于监测CAG癌前病变的进展及胃癌的早期发现．AIM： To investigate the expression of P53 and C-erbB-2 proteins in chronic atrophic gastritis （CAG） and their correlation with clinicopathological parameters in CAG. METHODS： SP immunohistochemistry was used to detect the expression of P53 and C-erbB-2 proteins in normal gastric mucosa （n = 56）, chronic atrophic gastritis with cystic dysplasia （n = 61）, intestinal metaplasia （n = 73）, atypical hyperplasia （n = 295） and early gastric carcinoma （n = 57）. The relationship between the expression of P53 and C-erbB-2 and the clinicopathological characteristics were analyzed. RESULTS： The positive rates of P53 and C-erbB-2 protein expression were increased with the malignant degrees of gastric tissues. There were significant differences between normal gastric mucosa, moderate atypical hyperplasia, intestinal metaplasia, severe atypical hyperplasia and gastric carcinoma （P 〈 0.01）. The expression of P53 was notably correlated with the age and gender of patients （X^2 = 12.393, P 〈 0.01; X^2= 8.799, P 〈 0.01）, while C-erbB-2 expression was just correlated with the age of patients （X^2 = 7.706, P 〈 0.01）. Besides, the expression of P53 was positively correlated with that of C-erbB-2 （r = 0.867, P 〈 0.05）. CONCLUSION： P53 and C-erbB-2 expression have significant correlations with the malignancy progression in CAG, and they can help to make early diagnosis for gastric cancer.

关 键 词：慢性萎缩性胃炎 P53 C—erbB-2 胃癌 免疫组织化学 

分 类 号：R573.3[医药卫生—消化系统]