胸腺瘤组织Cat V表达与合并重症肌无力的临床病理生理特征的关系研究  

Relationship Between Expression of Cat V and Clinicopathologic Character of Myasthenia Gravis in Patients with Thymoma

作　　者：王允[1] 黄颐[2] 罗德云[3] 袁强[4] 龚仁蓉[1] 仇桂东[1] 

机构地区：[1]四川大学华西医院胸外科,成都610041 [2]四川大学华西医院精神卫生中心 [3]四川大学华西医院肿瘤中心 [4]四川大学华西医院神经内科

出　　处：《四川大学学报（医学版）》2006年第6期886-888,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30100181);四川大学青年科技基金资助

摘　　要：目的研究胸腺瘤组织中CatV表达与患者合并重症肌无力(myastheniagravis,MG)及临床病理生理特征之间的关系。方法采用免疫组织化学SP法检测78例胸腺瘤患者胸腺瘤组织和瘤旁胸腺组织中的CatV表达水平,分析其与胸腺瘤患者合并发生MG及其临床病理生理特征之间的关系。结果CatV在胸腺瘤组织及瘤旁胸腺组织中均有阳性表达;在瘤旁胸腺组织中,CatV主要在皮质细胞中表达。合并MG胸腺瘤患者的胸腺瘤组织(82.50%)及瘤旁胸腺组织(77.50%)中CatV阳性表达率均高于不合并MG组(分别为26.33%、31.58%)(P均<0.01);在MG组中,型(92.00%)、型(83.33%)患者的CatV阳性表达率显著高于型(55.56%)患者(P<0.05);而术后发生肌无力危象组与未发生危象组,病程在1年以内患者与超过1年患者的CatV阳性表达率差异无统计学意义。上皮细胞型(75.00%)和混合细胞型(85.00%)胸腺瘤中CatV阳性表达率显著高于淋巴细胞型(21.21%)(P<0.01),而上皮细胞型与混合细胞型之间差异无统计学意义;良性与恶性胸腺瘤中CatV阳性表达率差异无统计学意义;男性患者与女性患者之间、35岁以上患者与以下患者之间胸腺瘤中CatV阳性表达率差异均无统计学意义。结论胸腺瘤中CatV表达可能与合并发生MG有关。Objective To investigate the association of expression of Cat V with the clinicopathologic variables of myasthenia gravis （MG） in patients with thymoma. Methods Seventy-eight patients with thymomas were involved. Immunohistochemical method was adopted in investigating the protein expression of Cat V in the thymomas and thymic tissues adjacent to thymomas. Results The protein of Cat V could be detected in both thymomas and. thymic tissues. And the cortex was the main expressive domain of Cat V in thymus. The positive ratio of Cat V expression in thymoma was significantly increased in patients with MG, compared with that in patients without MG （82.50% vs 26.33%, P〈0. 01）, and similar results were observed in thymic tissues adjacent to tumors （77.50% vs 31.58%, P〈0. 01）. Analysis on the relationship of the clinical subtypes of MG with expression of Cat V revealed that the positive ratio in type Ⅱ （92. 00%） and type Ⅲ （83.33%） was much higher than that in type Ⅰ （55.56%） （P〈0. 05）. The expression of Cat V was significantly raised in the epithelial-rich and mixed cell thymomas when compared with that in the lymphocyte-rich ones. No statistically significant difference was found on the variables such as perioperative myasthenic crisis, sex or age of patient, duraton of sickness and expression of Cat V. Conclusion The overexpression of Cat V in thymomas may be associated with MG.

关 键 词：CAT V基因 胸腺瘤 重症肌无力 

分 类 号：R736.3[医药卫生—肿瘤]