吲哚胺2,3-二氧化酶与免疫系统功能调节  

Regulatory effect of indoleamine 2,3-dioxygenase on immune system

作　　者：付云峰[1] 任永欣[1] 杨以阜[1] 左建平[1] 

机构地区：[1]中国科学院上海药物研究所免疫药理学研究室,上海201203

出　　处：《中国药理学通报》2006年第11期1296-1299,共4页Chinese Pharmacological Bulletin

基　　金：中科院知识创新项目资助课题(NoKSCX2-SW-202);国家自然科学基金资助课题(NoA30171086);上海市科学技术委员会科研计划项目资助课题(No03DZ19228)

摘　　要：免疫应答受多种因素影响和调节,从而维持机体内环境的稳定。巨噬细胞、树突状细胞等抗原提呈细胞表达的吲哚胺2,3-二氧化酶(Indoleam ine 2,3-d ioxygenase,IDO)清除局部微环境中的色氨酸,诱导T淋巴细胞的凋亡,通过调节性T细胞的作用抑制T细胞的克隆性增生,参于细胞免疫的调节;在机体维持正常的妊娠以及自身免疫性疾病、器官移植排斥反应、肿瘤等疾病的发生发展中起着重要作用。调控IDO的活性可能是寻找防治免疫相关性疾病药物的新途径。The regulation of immune response is affected by several factors in order to maintain homeostasis. Indoleamine 2,3-dioxygenase （IDO） is a tryptophancatabolizing enzyme expressed by different types of APC, including macrophages and dendritic cells. IDO activity leads to regulatory effects on T cells, which are mediated by tryptophan depletion in specific local tissue microenvironments, the production of proapoptotic metabolites, and inhibition of T-cell clone proliferationthrough regulatory T cells. IDO plays an important role in protecting the allogeneic fetus from rejection, the development of autoimmune diseases, allograft rejection, and cancer. So regulation of IDO activity may offer a novel drug-based strategy to treat immune-related diseases.

关 键 词：吲哚胺2  3-二氧化酶 色氨酸 细胞免疫 

分 类 号：R-05[医药卫生] R329.25