神经病理痛动物模型及其在P2X受体介导痛觉研究中的应用  

Animal model of neuropathic pain and its application to research on pain mediated by P2X receptors

作　　者：高云[1] 梁尚栋[1] 

机构地区：[1]南昌大学医学院生理学教研室,江西南昌330006

出　　处：《中国药理学通报》2006年第11期1310-1314,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题(No30260030)

摘　　要：神经病理痛是临床上常见病症,对人身心健康危害较大,其发病机制尚不清楚,目前无有效的治疗手段,加之慢性神经病理痛持续时间长,其研究成为疼痛领域的热点和重点。该文综述的多种神经病理痛的动物模型,复制了人类神经病理痛的各种症状,是研究神经病理痛的有效手段。三磷酸腺苷(ATP)是一种重要的疼痛信号物质,ATP可作用于P2X受体产生效应。应用神经病理痛动物模型,观察到P2X受体在神经病理痛的痛觉形成、传导和调节中有着重要作用,有望成为神经病理痛治疗的新作用位点。Neuropathic pain is the clinically common disease and does great harm to physical and mental health. Because its pathogenesis is still unclear andthere aren＇t effective therapeutic tools and the course of chronic pain lasts a long time, the study of neuropathic pain has become the hot spot and the focal point ofpain research area. This article reviews various kinds of animal models of neuropathic pain, which can repeat neuropathic pain symptoms of mankind and may be effective ways to make research. By acting on P2X receptors, ATP is the signal of an important transmittingpain. By utilizing animal models of neuropathic pain, it shows that P2X receptors have an important role in the formation, transmission and regulation of pain and may be a new target of neuropathic pain therapy.

关 键 词：神经病理痛 三磷酸腺苷 P2X受体 

分 类 号：R-05[医药卫生] R322.8