Fra-1原癌基因研究进展  

Proto-oncogene Fos-related antigen(Fra) 1:research progress

作　　者：宋玉华[1] 郭宁[1] 宋三泰[2] 江泽飞[2] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850 [2]军事医学科学院附属医院,北京100071

出　　处：《军事医学科学院院刊》2006年第5期490-493,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：北京市自然科学基金重点项目(No.7051006)

摘　　要：原癌基因Fra-1是核转录因子AP-1家族的成员,通过亮氨酸拉链结构域与Jun蛋白形成异源二聚体,调控靶基因的转录。在胚胎发育过程中,通过促进成骨细胞、破骨细胞分化,影响骨基质蛋白的合成,参与骨形成。近年来,发现Fra-1在恶性肿瘤的迁徙、侵袭中发挥着重要的作用,其可能成为肿瘤治疗的新靶点。本文综述了Fra-1在骨形成及肿瘤中的研究进展。A proto-oncogene Fos-related antigen（Fra） -1 is a FOS family member and an AP-1 transcription factor component. Through their leucine zipper domain, Fra-1 proteins form heterodimers with Jun proteins,which control transcription of target gene. In embryo developmental processes, Fra-1 can regulate bone mass by affecting osteoblast/osteoclast differentiation and bone matrix production. In recent years, it has been shown that Fra-1 may play an important role in malignant tumor motility and invasiveness. It may be a potential therapeutic target. Here ,the role of Fra-1 in regulating bone formation and its role in tumorigenesis are reviewed.

关 键 词：Fra-1 原癌基因 骨生成 肿瘤 运动和侵袭 

分 类 号：R730.2[医药卫生—肿瘤]