老年高血压伴发抑郁症患者的临床研究  

A clinical study of older patients with hypertension coexisting depression

作　　者：苏海霞[1] 成静[1] 蔡文玮[1] 杜勤[1] 盛净[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院老年科,上海市200011

出　　处：《中国行为医学科学》2006年第11期999-1000,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的观察抑郁症对老年高血压患者临床指标的影响,及常见合并症与抑郁症发生的相关性。方法选择内科住院的年龄大于65岁的高血压患者,抑郁症和非抑郁症各46例,对2组的临床资料和生化指标进行统计学分析。结果抑郁症组患者的心率较快[(77.74±5.62)次/minvs(71.23±8.36)次/min,P=0.041],血清纤维蛋白原含量较高[(3.55±0.59)g/Lvs(2.95±0.67)g/L,P=0.028],心脏舒张末期内径较大[(56.31±2.31)mmvs(53.26±2.83)mm,P=0.012],而高密度脂蛋白较低[(1.11±0.17)mmol/Lvs(1.36±0.35)mmol/L,P=0.025],心输出量较低[(5.90±0.96)L/minvs(7.42±1.64)L/min,P=0.038];多元回归分析显示糖尿病和脑梗死与抑郁症发生明显相关,偏相关系数分别为10.63和3.79,P<0.01。结论患抑郁症的老年高血压患者心功能降低,且有形成血栓的倾向;合并糖尿病和脑梗死是抑郁症的促发因素。Objective To explore the effect of depression on older patients with hypertension , and the relationship of other coexisting diseases and depression. Methods 92 patients aged 65 years and over with hypertension were chosen as subjects. HAMD were evaluated , clinical data were collected directly from their medical record. Results Compared with control group, the hard rate, end of diastole dimension, serum concentration of fibrinogen and BUN increased significantly, whereas the HDL-C and cardiac output decreased significantly. Analysis of multiple regression showed that diabetes and stroke were related with depression, and the regressive coefficient were 10.63 and 3.79, P 〈 0.01. Conclusion The patients coexisting with depression have a tendency of thrombus and hard failure, and diabetes and stroke were independent risk factors for depression.

关 键 词：抑郁症 高血压 糖尿病 脑梗死 

分 类 号：R749.2[医药卫生—神经病学与精神病学]