养肝清热颗粒对实验性肝炎的保护作用  

Protective effects of Yangganqingrekeli on experimental hepatitis

作　　者：刘崇俊[1] 吴宏丽[1] 乌冬梅[1] 

机构地区：[1]大连市中医医院,辽宁大连116013

出　　处：《中医药学刊》2006年第11期2109-2110,共2页Study Journal of Traditional Chinese Medicine

摘　　要：目的:观察养肝清热颗粒的抗实验性肝炎作用。方法:分别采用四氯化碳(CCl4)和D-半乳糖胺(D-GalN)诱导小鼠发生实验性急性肝损伤。结果:养肝清热颗粒可对抗四氯化碳和D-半乳糖胺所致血清中ALT、AST、ALP升高及GSH降低,并减轻D-半乳糖胺所致肝脏病变程度,其中以中剂量(相当于生药80g/kg)预防给药7天效果最佳。结论:养肝清热颗粒对实验性肝炎有保护作用。Objective： To study the protective effects of Yangganqingrekelion experimental hepatitis. Methods： Mice acute liver injury model was induced by CCl4 or D -galactosamine （D - GL）. Results： the decrease of ALT, AST, ALP, and the increase of GSH inserum which were induced by CCl4 or D - GL could be resisted by Yangganqingrekeli, the hepato - cellular degeneration and necrosis induced by D- GL could also be diminished. The best dosage is （80g/kg · d^-1 ,7d, ig）. Conclusion： Pretreatment with Yangganqingrekeli moderately prevents the liver damage induced by CCl4 or D - GL.

关 键 词：齐肝清热颗粒 D-半乳糖胺 四氯化碳 实验性肝炎 中医药疗法 

分 类 号：R-33[医药卫生]