DNA甲基化与胶质瘤  

DNA methylation and glioma

作　　者：姜政[1] 李新钢[1] 胡锦[1] 

机构地区：[1]山东大学齐鲁医院神经外科实验室,济南250012

出　　处：《国际肿瘤学杂志》2006年第11期867-870,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目(30371459)

摘　　要：表遗传学修饰的DNA甲基化在胶质瘤的发生发展中起重要作用。大量肿瘤抑制基因、细胞周期调控基因、DNA损伤修复基因、肿瘤侵袭相关基因等启动子区域CpG岛甲基化,与胶质瘤的发生发展密切相关。不同基因的甲基化发生频率与胶质瘤的组织类型和病理分级有关。某些基因的DNA甲基化可以为胶质瘤的早期诊断和预后评价提供分子生物学标记物,同时由于DNA甲基化具有可逆转性,也可为胶质瘤的基因治疗提供新的治疗靶点。DNA methylation modified by epigenetic mechanism plays an important role in the genesis and development of glioma. The CpG island methylation in promoter region of tumor suppressor genes （TSG）, cell cycle controlling genes, DNA repair genes and tumor invasion related genes is closely correlated with the development of glioma. The frequency of methylation in different genes is related with the tissue type and pathology class of glioma. The DNA methylation of some genes may be offered as molecular biological marker of early diagnosis and prognostic evaluation. At the same time, DNA methylation may be also used as a new target of glioma treatment for the reversibility of DNA methylation.

关 键 词：神经胶质瘤 DNA甲基化 

分 类 号：R739.4[医药卫生—肿瘤]