30岁以下乳腺癌临床病理特征及分子生物学特点分析  

Clinical characteristics and molecular biological features analysis of breast cancer in women under 30 years of age

作　　者：周涛[1] 陈丽芬[1] 耿翠芝[1] 王桂兰[1] 王小玲[2] 

机构地区：[1]河北医科大学附属第四医院外一科,石家庄050011 [2]河北医科大学附属第四医院病理科,石家庄050011

出　　处：《国际肿瘤学杂志》2006年第11期874-877,共4页Journal of International Oncology

摘　　要：目的探讨30岁以下青年乳腺癌的临床病理学特征及分子生物学特点。方法回顾性分析105例30岁以下青年女性单侧原发性乳腺癌患者的临床和病理资料,并与157例同期随机选取的中老年乳腺癌患者作对照,分析其病理类型、临床分期、腋淋巴结状况、雌激素受体(ER)、孕激素受体(PR)、C-erbB2及血管内皮生长因子(VEGF)蛋白表达状况。结果青年乳腺癌误诊率为45．71％;以浸润性导管癌为主,但浸润性小叶癌占27．9％,明显高于对照组(P= 0．039);腋淋巴结转移率、C—erbB2和VEGF蛋白表达水平均高于对照组,ER、PR水平低于对照组(P<0．05);两组临床分期无统计学差异(P>0．05)。结论30岁以下青年乳腺癌具有独特的病理学特征和分子生物学特点,且误诊率高,进展快,转移早,提示预后差;患者年龄不是影响乳腺癌预后的独立指标;早期诊断是提高青年乳腺癌患者生存率的唯一有效手段。Objective To study the clinical characteristics and molecular biological features of breast cancer in women under 30 years of age. Methods The clinical and pathological data of 105 cases of unilateral primary breast cancer in women under 30 years of age were reviewed and compared with 157 cases of breast cancer selected randomly in other group of age at contemporaneity. Pathological type, clinical stage, states of axillary lymph nodes metastasis , estrogen receptor, progesterone receptor, C-erbB2 and VEGF were detected and the statistic data were analyzed by SPSS 11.5. Results The incidence rate of breast cancer in women under 30 years of age was 3.97 %, misdiagnosis rate was 45.71% ; Infiltrated ductal carcinoma was the primary pathological type in young group as well as group of middle and old age, but the percentage of infiltrated lobular carcinoma showed statistical difference compared with the control group （ P 〈 0. 05）. The rate of axillary lymph nodes metastasis, protein expression of C-erbB2 and VEGF in group of women under 30 years of age were higher , but the positive rate of ER and PR were lower than those of the control group（ P 〈 0. 05） ; No significant difference of clinical stages between the two groups was found. Conclusion Breast cancer in women under 30 years of age has distinct clinical characteristics and molecular biological features, which show unfavorable prognosis including higher rate of misdiagnosis, quicker development, early metastasis;age is not an independent prognostic indicator;early diagnosis is the only effective pathway which would enhance the survival rate of breast cancer in young women.

关 键 词：乳腺肿瘤 青少年 免疫组织化学 血管内皮生长因子受体类 C-ERBB2 

分 类 号：R737.9[医药卫生—肿瘤]