宫颈癌中RASSF1A基因高度甲基化及微卫星变异的研究进展  

Progress of Hypermethylation and Microsatellite Alterations of RASSF1A in Cervical Carcinoma

作　　者：燕杰[1] 赵富玺[1] 

机构地区：[1]山西大同大学医学院病原生物与免疫学研究所,山西大同037008

出　　处：《医学综述》2006年第22期1368-1370,共3页Medical Recapitulate

摘　　要：新近克隆出来的Ras相关区域家族1A基因(RASSF1A)已被确认为一种候选抑癌基因(TSGs),位于人类染色体3p21.3上。RASSF1A基因失表达见于多种人类肿瘤中,如肺癌、乳腺癌、肝癌、宫颈癌、肾癌等,表明了其在致癌作用中的重要性。高度甲基化和微卫星变异(mic-rosatellite alterations)是导致RASSF1A基因失活的主要机制,其参与了细胞凋亡信号的转导、微管的稳定作用和有丝分裂的进程,作为一种Ras负向调节因子阻止细胞生长,诱导细胞凋亡,促进肿瘤的发生和发展。宫颈癌中存在RASSF1A基因的表达缺失,且与人乳头状瘤病毒(HPV)感染之间存在一定的相关关系。Recent cloned Ras association domain family 1A gene has been considered as a new candidated anti-oncogen, which is located on human chromosome 3p21.3. RASSF1A is found to be inactivated in several major human cancers including lung, brest, liver, cervix, kidney and other cancers, which implicates its significance in carcinogenesis. Hypermethylation and microsatalliter alterations are the main mechanism resuiting in activation, which takes part in the signal transduction of cell apoptosis, stabalization of microtubular and proceeding of mitosis, as well as inhibits the growth of cells and induces cell apoptosis as down-regulatory factor of Ras and then promote the occurrence and development of tumor. Cervical cancer has genie expression deletion of RASSF1A and has somewhat correlativity with the infection of HPV.

关 键 词：宫颈肿瘤 RASSF1A基因 高度甲基化 微卫星变异 人乳头状瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]